Scientific Papers

This study introduces a novel, cost-effective TLC-based method for quantifying quillaic acid, the core aglycone of important saponin adjuvants like QS-21, which are widely used to enhance vaccine [...]

This review article highlights the mechanistic insights and clinical evidence supporting their use within combination formulations, such as AS01, which contains QS-21 saponins. It emphasizes how [...]

This study is a pioneering evaluation of the Immune-Stimulating Particle Adjuvant (ISPA), a saponin-based particulate platform related to ISCOMATRIX, in enhancing recombinant subunit vaccines [...]

This paper provides a comprehensive analysis of the global supply chain for quillay-derived saponin adjuvants, particularly QS-21, that are essential components of several high-impact vaccines [...]

This paper explores the application of CoPoP liposome-based nanotechnology, particularly focusing on the incorporation of saponins like QS-21 as adjuvants, to enhance vaccine efficacy in [...]

This paper is about another adjuvant formulation method with QS-21. This study presents a novel approach to improving the safety and efficacy of QS-21, a potent saponin adjuvant widely used in [...]

This paper describes the development of a vaccine controlling Staphylococcus aureus-induced mastitis in dairy cattle, using saponin-based adjuvants, NanoQuil, a third-generation immunostimulating [...]

This paper is significant for its innovative use of the saponin adjuvant QS-21 in a self-adjuvanting vaccine targeting melanoma. The authors designed a GM3-based conjugate vaccine that [...]

This review paper provides a comprehensive overview of recent advances in the heterologous biosynthesis of QS saponins, with a particular focus on QS-21. It highlights the significance of QS-21 [...]

This article presents a compelling case for the development of an Epstein–Barr virus (EBV) vaccine, emphasizing the potential role of saponin-based adjuvants such as Matrix-M in enhancing vaccine [...]