Lützelschwab, C., et al. Evaluation of a novel experimental NanoQuil vaccine against Staphylococcus aureus-induced mastitis. J Dairy Res. 2026 May 22:1-8. PMID: 42170826

This paper describes the development of a vaccine controlling Staphylococcus aureus-induced mastitis in dairy cattle, using saponin-based adjuvants, NanoQuil, a third-generation immunostimulating complex (ISCOM) nanoparticle formulation. As
mastitis remains a major health and economic concern in dairy farming worldwide, with current vaccines showing limited efficacy, this study's focus on a novel NanoQuil adjuvant combining with formalin-fixed bacterial antigens is particularly
relevant. The research is unique because it evaluates the real-world performance of this innovative adjuvant in a herd setting, comparing it with a commercial vaccine, while also providing insights into immune responses, herd udder health, and
infection dynamics.

Although the vaccine did not significantly outperform the current commercial product in key parameters, the findings suggest that saponin-based NanoQuil formulations may contribute to improved herd udder health and recovery rates, emphasizing their
potential role in advancing