Gotham, D., et al. Understanding adjuvant supply chains for new TB and malaria vaccines. Vaccine, 2026 May 22, 82:128609. PMID: 42025104
This paper provides a comprehensive analysis of the global supply chain for quillay-derived saponin adjuvants, particularly QS-21, that are essential components of severa...
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Oboge, H., et al. Immunogenicity of Theileria parva p67C Antigen Delivered via Adjuvanted CoPoP Liposomes in Cattle and Mice. Vaccines (Basel). 2026 May 20, 14(5):459. PMID: 42188829
This paper explores the application of CoPoP liposome-based nanotechnology, particularly focusing on the incorporation of saponins like QS-21 as adjuvants, to enhance vac...
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Márquez, P.G., et al. Cooperative supramolecular integration of QS-21 into polymeric micelles as a tunable nanoadjuvant platform for subunit vaccines. RSC Adv. 2026 May 1, 16(25):22897-22915. PMID: 42080164
This paper is about another adjuvant formulation method with QS-21. This study presents a novel approach to improving the safety and efficacy of QS-21, a potent saponin a...
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Lützelschwab, C., et al. Evaluation of a novel experimental NanoQuil vaccine against Staphylococcus aureus-induced mastitis. J Dairy Res. 2026 May 22:1-8. PMID: 42170826
This paper describes the development of a vaccine controlling Staphylococcus aureus-induced mastitis in dairy cattle, using saponin-based adjuvants, NanoQuil, a third-gen...
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Liang, R., et al. Ganglioside GM3 and Lipid A Mimetic Conjugate Combined with EcMPLA and QS-21 as a Potential Vaccine Candidate for Cutaneous Melanoma Immunotherapy. J Med Chem, 2026 May 14, 69(9):11434-11447. PMID: 42077094
This paper is significant for its innovative use of the saponin adjuvant QS-21 in a self-adjuvanting vaccine targeting melanoma. The authors designed a GM3-based conjugat...
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Tian, Y., Advances in the heterologous biosynthesis of QS saponins: a review. Microb Cell Fact. 2026 May 26. PMID: 42192394
This review paper provides a comprehensive overview of recent advances in the heterologous biosynthesis of QS saponins, with a particular focus on QS-21. It highlights th...
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Akingbola, A., et al. The case for an Epstein-Barr virus vaccine: Lessons from its link to systemic lupus erythematosus. Hum Vaccin Immunother, 2026 Dec, 22(1):2657719. PMID: 41964170
This article presents a compelling case for the development of an Epstein–Barr virus (EBV) vaccine, emphasizing the potential role of saponin-based adjuvants such as Matr...
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Roussy, J.F., et al. Immunogenicity and Safety of the Adjuvanted Respiratory Syncytial Virus Prefusion F Protein-Based Vaccine When Co-administered With the Adjuvanted Recombinant Herpes Zoster Subunit Vaccine in Adults ≥ 50 Years of Age. Clin Infect Dis, 2026 Apr 29, ciag208. PMID: 42054374
This phase III open-label study evaluates the immunogenicity and safety of co-administering two adjuvanted vaccines: the AS01E-adjuvanted RSV prefusion F protein vaccine ...
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