Haupt, S., et al. Rapid boosting increases germinal center responses to sequential vaccines. Nat Immunol, 2026 Jul, 27(7):1476-1489. PMID: 42337116
This paper explores how rapid boosting strategies can significantly enhance germinal center (GC) responses in the context of HIV vaccination, particularly emphasizing the...
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Kilic, G., et al. Age-related differences in immune responses to inactivated influenza and adjuvanted recombinant herpes zoster vaccines. JCI Insight, 2026 Jun 2. PMID: 42228420
This paper uniquely explores how the adjuvant AS01 enhances immune responses in aged populations, focusing on its role in overcoming immunosenescence. By comparing respon...
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Dagnew, A.F., et al. Design and feasibility considerations for a phase 3 efficacy trial of the M72/AS01E-4 tuberculosis vaccine. Vaccine, 2026 Jul 11, 85:128690. PMID: 42119392
This paper presents the design and feasibility considerations for a phase 3 efficacy trial of the M72/AS01E-4 tuberculosis vaccine, which incorporates the AS01 adjuvant s...
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Zarrinpanah, T., et al. Next-generation vaccine adjuvants: Integrating nanotechnology, systems immunology, and computational approaches for precision vaccinology. Hum Vaccin Immunother, 2026 Dec, 22(1):2684345. PMID: 42405958
This paper offers a comprehensive overview of next-generation vaccine adjuvants, with particular emphasis on nanotechnology, systems immunology, and computational approac...
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Bogoyavlenskiy, A., et al. Nanoparticle Engineering in Modern Vaccinology: From Delivery Platforms to Immune-Programming Architectures. Molecules, 2026 Jul 17, 31(14):2501. PMID: 42513179
This paper provides a comprehensive overview of advanced nanoparticle-based vaccine platforms, including a focused emphasis on saponin-derived self-assembling nanoplatfor...
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Jansen, J., et al. Adjuvants MPLA and SMNP induce antiviral immunity and indirectly revert HIV-1 latency. PLoS One, 2026 Jul 20, 21(7):e0348959. PMID: 42475333
This paper is a significant contribution to the field of saponin-based adjuvants, particularly highlighting the potent immunostimulatory capacity of the saponin-MPLA nano...
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King, H.A.D., et al. Rapid and robust immune response boosting with potent, next-generation adjuvant in viral vector-primed primates. J Virol, 2026 Jul 27, e0038926. PMID: 42505121
This paper presents a comprehensive evaluation of the next-generation liposomal saponin-based adjuvant, ALFQ, in a primate model of HIV-1 vaccination, highlighting its ca...
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Ge, J., et al. Development and Preliminary Mechanistic Evaluation of a Novel Liposomal QS-21 and CpG ODNs Adjuvant System for Enhancing Vaccine Immunogenicity. Vaccines (Basel), 2026 Jun 5, 14(6):510. PMID: 42347631
This paper presents a novel liposomal formulation combining QS-21, a potent saponin adjuvant, with CpG ODNs to synergistically enhance Th1-biased immune responses, offeri...
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