News - Desert King

Akingbola, A., et al. The case for an Epstein-Barr virus vaccine: Lessons from its link to systemic lupus erythematosus. Hum Vaccin Immunother, 2026 Dec, 22(1):2657719. PMID: 41964170

This article presents a compelling case for the development of an Epstein–Barr virus (EBV) vaccine, emphasizing the potential role of saponin-based adjuvants such as Matr...

Roussy, J.F., et al. Immunogenicity and Safety of the Adjuvanted Respiratory Syncytial Virus Prefusion F Protein-Based Vaccine When Co-administered With the Adjuvanted Recombinant Herpes Zoster Subunit Vaccine in Adults ≥ 50 Years of Age. Clin Infect Dis, 2026 Apr 29, ciag208. PMID: 42054374

This phase III open-label study evaluates the immunogenicity and safety of co-administering two adjuvanted vaccines: the AS01E-adjuvanted RSV prefusion F protein vaccine ...

Kinsey, C., et al. A Versatile Reversed-Phase Liquid Chromatography Charged Aerosol Detection Method for Streamlined Monitoring of QS-21 Content and Stability in Liposomal Adjuvant Formulations. https:// doi.org/10.26434/chemrxiv.15002275/v1. Posted on 21 April 2026 (this preprint has not been peer reviewed. Data may be preliminary)

This study introduces a novel, versatile liquid chromatography method coupled with charged aerosol detection (LC-CAD) for the reliable quantification and stability monito...

Fang, A., et al. A model-based prion vaccine protects a transgenic mouse line carrying a Gerstmann-Sträussler-Scheinker disease mutation. Acta Neuropathol, 2026 Apr 17, 151(1):41. PMID: 41995880

This paper introduces a novel, structure-based prion vaccine that effectively targets the infectious form of the prion protein (PrP^Sc) by mimicking its disease-specific ...

Sia, Z.R., et al. Preparing Adjuvanted Nanoliposomes for Applications Toward Recombinant Influenza Vaccine Development. Bio Protoc, 2026 Apr 5, 16(7):e5662. PMID: 41971165

This paper, closely related to the previous one, presents a novel platform for developing recombinant influenza vaccines using adjuvanted nanoliposomes that incorporate s...

Li, Q., et al. Quillaja saponaria fraction QS-18 as an adjuvant for liposomal seasonal influenza vaccines. NPJ Vaccines, 2026 Apr 28, PMID: 42049779

This study presents a pioneering evaluation of QS-18, an abundant fraction from Quillaja saponaria, as a vaccine adjuvant within liposomal formulations for seasonal influ...

Gotham, D., et al. Understanding adjuvant supply chains for new TB and malaria vaccines. Vaccine, 2026 Apr 22, 82:128609. PMID: 42025104

This paper provides a comprehensive analysis of the global supply chain for Quillaja-derived saponin adjuvants, notably QS-21, which are pivotal components in several rec...

Padilla, L., et al. The challenge of one billion adjuvanted vaccine doses: evaluating scalability, sustainability, and supply capacity of Quillaja saponin QS-21 for large-scale vaccine demand. Front Immunol, 2026 Apr 17, 17:1813847. PMID: 42079571

This original paper from Desert King provides a comprehensive evaluation of the scalability, sustainability, and supply capacity of QS-21, a highly potent saponin adjuvan...