News - Desert King

Gonzalez, H.L.d.M., et al. Efficacy of LaAg Vaccine Associated with Saponin Against Leishmania amazonensis Infection.

The study evaluated different vaccine formulations incorporating Leishmania amazonensis antigens (LaAg) combined with various adjuvants, including complete Freund’s adjuv...

Venkatraman, N., et al. R21 in Matrix-M adjuvant in UK malaria-naive adult men and non-pregnant women aged 18-45 years: an open-label, partially blinded, phase 1-2a controlled human malaria infection study.

The study evaluates the efficacy and safety of the R21 malaria vaccine candidate (Jenner Institute, University of Oxford) formulated with the Matrix-M adjuvant (Novavax) ...

Ramezani-Rad, .P, et al. The saponin monophosphoryl lipid A nanoparticle adjuvant induces dose-dependent HIV vaccine responses in non-human primates.

The use of an appropriate adjuvant is crucial for developing an effective HIV vaccine. This study investigates the efficacy of QS-21-based saponin/monophosphoryl lipid A ...

Zhu, Q., et al. Harnessing phytochemicals: Innovative strategies to enhance cancer immunotherapy.

The article explores the promising role of phytochemicals, particularly saponins like Quil A and its derivative QS-21 from Quillaja saponaria, in enhancing cancer immunot...

Gaspar, E.B., et al. Adjuvant-driven antibody response to use cows as biofactories of anti-SARS-CoV-2 neutralizing antibodies in colostrum.

Bovine colostrum has the potential to serve as a source of neutralizing antibodies for preventing viral infections due to the evolutionary homology between bovine and hum...

Hickey, J., et al. Two recombinant cytomegalovirus antigens formulated with the SPA14 adjuvant system: Impact of temperature, pH and excipients on the stability of each antigen and adjuvant component.

The study evaluated the stability of two recombinant Cytomegalovirus antigens (gB and Pentamer) formulated with the SPA14 adjuvant system, a liposomal formulation contain...

Huis In ’t Veld, L. G., et al. Saponin-based adjuvant uptake and induction of antigen cross-presentation by CD11b+ dendritic cells and macrophages.

The paper presents several key findings regarding saponin-based adjuvants (SBAs), particularly focusing on their mechanism of action and efficacy in enhancing immune resp...

Ye, L., et al. Effects of immune response on different nano-adjuvants combined with H11 antigen of Haemonchus contortus.

The study indicates that nano-adjuvants offer a promising alternative to traditional adjuvants for inducing robust and lasting immune responses, particularly in the conte...