Ge, J., et al. Development and Preliminary Mechanistic Evaluation of a Novel Liposomal QS-21 and CpG ODNs Adjuvant System for Enhancing Vaccine Immunogenicity. Vaccines (Basel), 2026 Jun 5, 14(6):510. PMID: 42347631
This paper presents a novel liposomal formulation combining QS-21, a potent saponin adjuvant, with CpG ODNs to synergistically enhance Th1-biased immune responses, offeri...
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Paillot, R., et al. Antibody Titres to Strangvac Antigens Correlate with Protection and Duration of Immunity Against Experimental Infection with Streptococcus equi Subspecies equi. Vaccines (Basel), 2026 Jun 16, 14(6):533. PMID: 42347654
This study investigates the immunological correlates of protection induced by Strangvac®, a recombinant fusion protein vaccine containing antigens from Streptococcus equi...
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Kumar, A., et al. Multifunctional saponin-based nanocarriers for targeting oral delivery of hydrophobic drugs: linking molecular architecture with bioavailability enhancement. Int J Pharm, 2026 Jul 10, 700:127035. PMID: 42217814
This comprehensive review highlights the emerging potential of saponin-based nanocarriers as versatile and sustainable adjuvants in drug and vaccine delivery, emphasizing...
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Qu, F., et al. Multi-Modal Characterization of the Interactions between a Recombinant Protein Antigen and a Liposomal Adjuvant. Mol Pharm, 2026 Jun 14. PMID: 42289982
This paper presents a comprehensive, multimodal investigation into the interactions between a recombinant glycoprotein E (gE) antigen and the liposomal adjuvant system AS...
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Fuentes. R., et al. Synthesis and In Vivo Immunological Evaluation of Novel Saponin-Antigen Conjugates Incorporating Tumor-Associated Carbohydrate and Peptide Epitopes. Chemistry, 2026 May 28:e71192. PMID: 42210026
This study introduces innovative saponin-based self-adjuvanting vaccine constructs that combine tumor-associated carbohydrate and peptide epitopes, leveraging a streamlin...
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Bülow, F.E., et al. A novel thin layer chromatography based method for the quantification of quillaic acid saponins. J Pharm Biomed Anal, 2026 Jun 15, 273:117409. PMID: 41687224
This study introduces a novel, cost-effective TLC-based method for quantifying quillaic acid, the core aglycone of important saponin adjuvants like QS-21, which are widel...
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Madelon, N., Didierlaurent, A.M. Combination adjuvants: clinical value and mechanisms of action. Curr Opin Virol, 2026 Jun 19, 76:101564. PMID: 42320106
This review article highlights the mechanistic insights and clinical evidence supporting their use within combination formulations, such as AS01, which contains QS-21 sap...
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Arcon, N., et al. The immune-stimulating particle adjuvant (ISPA) as a versatile adjuvant platform for recombinant vaccines against chronic Toxoplasma gondii infection. Acta Trop, 2026 Jun 23, 280:108197. PMID: 42336023
This study is a pioneering evaluation of the Immune-Stimulating Particle Adjuvant (ISPA), a saponin-based particulate platform related to ISCOMATRIX, in enhancing recombi...
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