Wei, L., et al. Saponin derivative and MPLA-adjuvanted intranasal protein nanoparticle vaccines induce potent mucosal immunity and durable heterologous influenza protection in mice
Nanomedicine, 2026 Aug 19:103008. PMID: 42617671 The authors introduce a novel intranasal protein nanoparticle influenza vaccine formulated with a semisynthetic saponin d...
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Lu, J., et al. Lysosomal disruption elicits immunogenic cell death: A saponin-nanoaluminum adjuvant for enhanced cancer immunotherapy
Acta Biomater, 2026 Aug, 220:276-291. PMID: 42468600 This paper introduces a novel saponin-based nanoadjuvant, QS-NanoAlum, that leverages lysosomal disruption to induce ...
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Eckhardt, E., et al. Comparison of the adjuvant effect of AS01, AS03 and alum on the immune response to GMP-grade H5N1 antigen in guinea pigs
Sci Rep, 2026 Aug 20, 16(1):26175. PMID: 42624960 Read this comprehensive comparison of the adjuvant effects of two advanced formulations, AS01 (containing QS-21 saponin ...
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Steichen, J.M., et al. Vaccination elicits HIV broadly neutralizing antibodies in primates
Nature, 2026 Aug, 656(8128):723-733. PMID: 42380658 Building upon the design of germline-targeted Env immunogens that effectively prime V2 apex bnAb precursors (see previ...
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Marchitto, L., et al. Enhanced B cell priming induces broadly neutralizing HIV-1 apex antibodies
Nature, 2026 Aug, 656(8128):712-722. PMID: 42380659 This Nature paper presents a significant advance in HIV vaccine design by demonstrating that germline-targeted Env imm...
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Tregunno, C., et al. AS01E-Adjuvanted Respiratory Syncytial Virus Prefusion F Protein Vaccine (Adjuvanted RSVPreF3): Review of the First 2 Years of Post-Marketing Safety Surveillance
Drug Saf, 2026 Aug 1. PMID: 42541670 Are you interested in a comprehensive two-year post-marketing safety surveillance of the AS01E-adjuvanted RSVPreF3 vaccine? This pape...
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Zhang, Y., et al. CD25+ cell depletion enhances protective immunity of PR8 inactivated influenza vaccine in aged mice. Virology, 2026 Aug, 621:110938. PMID: 42107283
This paper highlights the synergistic potential of combining saponin-based ISCOM adjuvants with immune regulatory modulation, specifically transient depletion of CD25+ re...
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Pyles, K., et al. Intranasal and intramuscular H5-Matrix-M nanoparticle vaccines protects against highly pathogenic H5N1 influenza virus in mice. NPJ Vaccines, 2026 Jul 10. PMID: 42431930
This study evaluates the immunogenicity and protective efficacy of a recombinant H5 hemagglutinin (HA) nanoparticle vaccine adjuvanted with Matrix-M, administered either ...
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