Scientific Papers

This paper presents a novel liposomal formulation combining QS-21, a potent saponin adjuvant, with CpG ODNs to synergistically enhance Th1-biased immune responses, offering a promising [...]

This study investigates the immunological correlates of protection induced by Strangvac®, a recombinant fusion protein vaccine containing antigens from Streptococcus equi and formulated with a [...]

This comprehensive review highlights the emerging potential of saponin-based nanocarriers as versatile and sustainable adjuvants in drug and vaccine delivery, emphasizing their ability to enhance [...]

This paper presents a comprehensive, multimodal investigation into the interactions between a recombinant glycoprotein E (gE) antigen and the liposomal adjuvant system AS01B, which contains [...]

This study introduces innovative saponin-based self-adjuvanting vaccine constructs that combine tumor-associated carbohydrate and peptide epitopes, leveraging a streamlined, synthetically [...]

This study introduces a novel, cost-effective TLC-based method for quantifying quillaic acid, the core aglycone of important saponin adjuvants like QS-21, which are widely used to enhance vaccine [...]

This review article highlights the mechanistic insights and clinical evidence supporting their use within combination formulations, such as AS01, which contains QS-21 saponins. It emphasizes how [...]

This study is a pioneering evaluation of the Immune-Stimulating Particle Adjuvant (ISPA), a saponin-based particulate platform related to ISCOMATRIX, in enhancing recombinant subunit vaccines [...]

This paper provides a comprehensive analysis of the global supply chain for quillay-derived saponin adjuvants, particularly QS-21, that are essential components of several high-impact vaccines [...]

This paper explores the application of CoPoP liposome-based nanotechnology, particularly focusing on the incorporation of saponins like QS-21 as adjuvants, to enhance vaccine efficacy in [...]