September 2026 - Desert King

Posted 16 September, 2026

Wei, L., et al. Saponin derivative and MPLA-adjuvanted intranasal protein nanoparticle vaccines induce potent mucosal immunity and durable heterologous influenza protection in mice

Nanomedicine, 2026 Aug 19:103008. PMID: 42617671 The authors introduce a novel intranasal protein nanoparticle influenza vaccine formulated with a semisynthetic saponin derivative, VSA-2, [...]

By Matias Bobadilla

In Scientific Papers

Posted 16 September, 2026

Lu, J., et al. Lysosomal disruption elicits immunogenic cell death: A saponin-nanoaluminum adjuvant for enhanced cancer immunotherapy

Acta Biomater, 2026 Aug, 220:276-291. PMID: 42468600 This paper introduces a novel saponin-based nanoadjuvant, QS-NanoAlum, that leverages lysosomal disruption to induce immunogenic cell death [...]

By Matias Bobadilla

In Scientific Papers

Posted 16 September, 2026

Eckhardt, E., et al. Comparison of the adjuvant effect of AS01, AS03 and alum on the immune response to GMP-grade H5N1 antigen in guinea pigs

Sci Rep, 2026 Aug 20, 16(1):26175. PMID: 42624960 Read this comprehensive comparison of the adjuvant effects of two advanced formulations, AS01 (containing QS-21 saponin and MPL-A) and AS03 (a [...]

By Matias Bobadilla

In Scientific Papers

Posted 16 September, 2026

Steichen, J.M., et al. Vaccination elicits HIV broadly neutralizing antibodies in primates

Nature, 2026 Aug, 656(8128):723-733. PMID: 42380658 Building upon the design of germline-targeted Env immunogens that effectively prime V2 apex bnAb precursors (see previous paper from Marchitto [...]

By Matias Bobadilla

In Scientific Papers

Posted 16 September, 2026

Marchitto, L., et al. Enhanced B cell priming induces broadly neutralizing HIV-1 apex antibodies

Nature, 2026 Aug, 656(8128):712-722. PMID: 42380659 This Nature paper presents a significant advance in HIV vaccine design by demonstrating that germline-targeted Env immunogens can rapidly prime [...]

By Matias Bobadilla

In Scientific Papers

Posted 16 September, 2026

Tregunno, C., et al. AS01E-Adjuvanted Respiratory Syncytial Virus Prefusion F Protein Vaccine (Adjuvanted RSVPreF3): Review of the First 2 Years of Post-Marketing Safety Surveillance

Drug Saf, 2026 Aug 1. PMID: 42541670 Are you interested in a comprehensive two-year post-marketing safety surveillance of the AS01E-adjuvanted RSVPreF3 vaccine? This paper employs the liposomal [...]