Scientific Papers

 Malaria remains a major global health challenge, particularly in endemic regions where effective vaccines are critically needed. Recent advances include the development of vaccines targeting [...]

 This paper emphasizes the growing global burden of dementia, particularly Alzheimer's disease, which is predicted to nearly double by 2050 due to aging populations worldwide. It [...]

 This study focuses on QS-21, a potent saponin adjuvant essential for human vaccines, traditionally sourced from the bark of mature Quillaja saponaria trees in Chile. The researchers identified a [...]

 The Quillaja saponaria tree, native to central Chile, has historically been valued for its soap-like bark containing saponins, which produce foam and have traditional cleaning uses. Its [...]

The paper explores how various adjuvants influence the immune response and hematopoietic pathways, particularly focusing on megakaryocytes and platelets, which are emerging as key players in [...]

This paper addresses the critical global health challenge posed by dengue virus, emphasizing the complexities in developing a safe, effective, and long-lasting vaccine capable of protecting [...]

This paper presents a novel, cost-effective thin-layer chromatography (TLC) -based method for quantifying quillaic acid saponins, key bioactive compounds with significant medicinal and [...]

This paper provides a comprehensive, data-driven forecast of global demand for the novel M72/AS01E tuberculosis vaccine, which has the potential to significantly reduce TB-related mortality [...]

Hudson, G.A., et al. Enzymology and Structural Basis of Glycosyltransferases Involved in Saponin C28 Carboxylic Acid OdFucosylation. JACS Au, 2025 Nov 24, 5(12):6011- 6024. PMID: 41450652   [...]

Hu, Y., et al. QS-21: Structural insights, immunological mechanisms, and prospects for rational design of safer vaccine adjuvants. Eur J Med Chem, 2026 Jan 5, 301:118223. PMID: 41046625   [...]