Scientific Papers

This paper presents the design and feasibility considerations for a phase 3 efficacy trial of the M72/AS01E-4 tuberculosis vaccine, which incorporates the AS01 adjuvant system. The primary focus [...]

This paper offers a comprehensive overview of next-generation vaccine adjuvants, with particular emphasis on nanotechnology, systems immunology, and computational approaches. The review [...]

This paper provides a comprehensive overview of advanced nanoparticle-based vaccine platforms, including a focused emphasis on saponin-derived self-assembling nanoplatforms such as ISCOMs and [...]

This paper is a significant contribution to the field of saponin-based adjuvants, particularly highlighting the potent immunostimulatory capacity of the saponin-MPLA nanoparticle adjuvant (SMNP) [...]

This paper presents a comprehensive evaluation of the next-generation liposomal saponin-based adjuvant, ALFQ, in a primate model of HIV-1 vaccination, highlighting its capacity to elicit rapid, [...]

This paper presents a novel liposomal formulation combining QS-21, a potent saponin adjuvant, with CpG ODNs to synergistically enhance Th1-biased immune responses, offering a promising [...]

This study investigates the immunological correlates of protection induced by Strangvac®, a recombinant fusion protein vaccine containing antigens from Streptococcus equi and formulated with a [...]

This comprehensive review highlights the emerging potential of saponin-based nanocarriers as versatile and sustainable adjuvants in drug and vaccine delivery, emphasizing their ability to enhance [...]

This paper presents a comprehensive, multimodal investigation into the interactions between a recombinant glycoprotein E (gE) antigen and the liposomal adjuvant system AS01B, which contains [...]

This study introduces innovative saponin-based self-adjuvanting vaccine constructs that combine tumor-associated carbohydrate and peptide epitopes, leveraging a streamlined, synthetically [...]