Wagner, A.A., et al. Accessing robust vaccine coformulation stability by single adjuvant detection on a microelectrode. Proc Natl Acad Sci U S A, 2025 Nov 4, 122(44):e2522044122. PMID: 41150712 The primary goal of this study is to develop and demonstrate a highly sensitive, single-particle analytical technique (stochastic electrochemistry) to assess the stability and interactions of […]

Komla, E., et al. Red blood cells as probes for determining free QS21 in liposomal adjuvant formulations to support product safety and stability. Anal Methods, 2025 Nov 20, 17(45):9162-9170.  PMID: 41196220 The goal of this study was to develop and validate a straightforward, reliable cell-based assay utilizing human red blood cells to detect and quantify […]

Uzar, S., et al. Formulation of inactivated and adjuvanted combined bovine rotavirus and bovine coronavirus candidate vaccine and immunity studies in mice. Vaccine, 2025 Nov 20, 67:127901, https://doi.org/10.1016/j.vaccine.2025.127901. This study aimed to develop and evaluate a safe and effective combined inactivated vaccine targeting bovine rotavirus (BRV) and bovine coronavirus (BCoV), pathogens that are leading causes […]

Lin, X.D., et al. Natural Compounds as Potential Therapeutics for Pancreatic Cancer: A Narrative Review. Curr Drug Metab, 2025 Sep 30. PMID: 41031495 The goal of this review is to comprehensively summarize recent research on natural compounds as potential therapeutics for pancreatic cancer (PC), highlighting their mechanisms of action, therapeutic potential, and the challenges faced […]

Liu, Y.F., et al. Anti-Colorectal Cancer Mechanisms of Natural Saponins: Advances and Therapeutic Implications. Chin J Integr Med, 2025 Oct 15. PMID: 41091371 This paper aims to systematically review the anti-colorectal cancer (CRC) effects of natural saponins, plant-derived compounds known for their low toxicity and multifaceted biological activities. Given the rising incidence and mortality of […]

Pifferi, C., et al. Design, synthesis and immunological evaluation of CRM197-based immunogens functionalized with synthetic scaffolds displaying a tumor-associated MUC1 glycopeptide. Biomater Sci, 2025 Nov 20. PMID: 41263603 This study aims to address the challenge of developing effective vaccines against tumor-associated MUC1 (taMUC1), a glycoprotein that is overexpressed and aberrantly glycosylated in many cancers but […]

Martins, A.Z., et al. Advances in recombinant protein vaccines against Leishmania infantum: a systematic review of vaccinal constructs and delivery strategies. Acta Trop, 2025 Oct, 270:107796. PMID: 40840696 This systematic review addresses the ongoing global health challenge posed by leishmaniasis, a neglected tropical disease caused by Leishmania infantum, with visceral leishmaniasis being particularly severe and […]

Campanharo, S.C., et al. Novel erythromycin lipid nanoformulations for aquaculture applications. J Appl Microbiol,  2025 Oct 6, 136(10):lxaf249. PMID: 41051220 The growing global demand for sustainable protein sources has heightened the importance of aquaculture, which faces significant challenges from bacterial infections that threaten fish health and productivity. Conventional antimicrobial treatments like erythromycin often suffer from […]