Scientific Papers

The development of an effective HIV-1 vaccine remains a global health priority due to the persistent high prevalence of HIV/AIDS despite advances in treatment and prevention strategies. While [...]

This paper provides an overview of QS-21, a potent saponin-based adjuvant derived from the bark of Quillaja saponaria, highlighting its significant role in enhancing both humoral and cellular [...]

Yue, S., et al. Purification of Quillaja saponins QS-21Xyl and QS-21Api by hydrophilic interaction chromatography. Carbohydr Res, 2025 Nov 8, 559:109741. PMID: 41223814 The primary goal of this [...]

Wagner, A.A., et al. Accessing robust vaccine coformulation stability by single adjuvant detection on a microelectrode. Proc Natl Acad Sci U S A, 2025 Nov 4, 122(44):e2522044122. PMID: 41150712 [...]

Komla, E., et al. Red blood cells as probes for determining free QS21 in liposomal adjuvant formulations to support product safety and stability. Anal Methods, 2025 Nov 20, 17(45):9162-9170.  [...]

Uzar, S., et al. Formulation of inactivated and adjuvanted combined bovine rotavirus and bovine coronavirus candidate vaccine and immunity studies in mice. Vaccine, 2025 Nov 20, 67:127901, [...]

Lin, X.D., et al. Natural Compounds as Potential Therapeutics for Pancreatic Cancer: A Narrative Review. Curr Drug Metab, 2025 Sep 30. PMID: 41031495 The goal of this review is to comprehensively [...]

Liu, Y.F., et al. Anti-Colorectal Cancer Mechanisms of Natural Saponins: Advances and Therapeutic Implications. Chin J Integr Med, 2025 Oct 15. PMID: 41091371 This paper aims to systematically [...]

Pifferi, C., et al. Design, synthesis and immunological evaluation of CRM197-based immunogens functionalized with synthetic scaffolds displaying a tumor-associated MUC1 glycopeptide. Biomater [...]

Martins, A.Z., et al. Advances in recombinant protein vaccines against Leishmania infantum: a systematic review of vaccinal constructs and delivery strategies. Acta Trop, 2025 Oct, 270:107796. [...]