Scientific Papers

Song, Y., et al.  50-Fold Adjuvant and 20-Fold Antigen Vaccine Dose Sparing from Nanoliposome Display of a Stabilized Malarial Protein Antigen. CS Nano, 2025 Mar 18, 19(10):10103-10112. PMID: [...]

Liu, H., et al. Harnessing natural saponins: Advancements in mitochondrial dysfunction and therapeutic applications. Phytomedicine, 2025 Mar, 138:156383. PMID: 39848019 The article reviews the [...]

Pal, P.B. and Lyer, S.S. Transient pain and long-term gain: adjuvant dose directs immune memory. J Clin Invest, 2025 Apr 15, 135(8):e190524. PMID: 40231461 The paper discusses the role of saponin [...]

Ramezani-Rad, P., et al. The saponin monophosphoryl lipid A nanoparticle adjuvant induces dose-dependent HIV vaccine responses in nonhuman primates. J Clin Invest, 2025 Mar 4, 135(8):e185292. [...]

Leroux-Roels, I., et al. Safety and Immunogenicity of an Adjuvanted Clostridioides difficile Vaccine Candidate in Healthy Adults: A Randomized Placebo-Controlled Phase 1 Study. J Infect Dis, 2025 [...]

Ison, M.G., et al. Efficacy, safety, and immunogenicity of the AS01E-adjuvanted respiratory syncytial virus prefusion F protein vaccine (RSVPreF3 OA) in older adults over three respiratory [...]

Venkatraman, N., et al. Evaluation of a novel malaria anti-sporozoite vaccine candidate, R21 in Matrix-M adjuvant, in the UK and Burkina Faso: two phase 1, first-in-human trials. Lancet Microbe, [...]

Haine, V., et al. Safety of RTS,S/AS01E malaria vaccine up to 1 year after the third dose in Ghana, Kenya, and Malawi (EPI-MAL-003): a phase 4 cohort event monitoring study. Lancet Glob Health, [...]

The study evaluates the efficacy and safety of the R21 malaria vaccine candidate (Jenner Institute, University of Oxford) formulated with the Matrix-M adjuvant (Novavax) in a phase 1–2a malaria [...]

The use of an appropriate adjuvant is crucial for developing an effective HIV vaccine. This study investigates the efficacy of QS-21-based saponin/monophosphoryl lipid A nanoparticle (SMNP) and [...]