Alsayeqh, A.F., et al. Saponins and their role as vaccine adjuvant against coccidiosis in poultry.

Alsayeqh, A.F., et al. Saponins and their role as vaccine adjuvant against coccidiosis in poultry. Kafkas Univ Vet Fak Derg, 2025 June 13, 31 (3): 351-359. 

• This paper explores the potential of saponins, plant-derived compounds, as vaccine adjuvants to combat coccidiosis in poultry, a disease caused by Eimeria species that results in significant economic losses and food safety concerns globally. Coccidiosis hampers poultry production due to its high prevalence and the limitations of current treatments, including drug resistance and toxicity. The study emphasizes the promise of natural saponins from plants such as Quillaja saponaria and Yucca schidigera in enhancing immune responses and vaccine efficacy, offering a safer and more effective alternative to conventional adjuvants. This research is significant because it aims to improve disease control strategies in poultry, thereby supporting food security, reducing economic impacts, and promoting safer meat and egg products.

• Comment: This review article focuses on previously published studies, examining various adjuvants and vaccine strategies. It synthesizes and critically evaluates findings from multiple sources but does not present any original experimental data or results generated by the authors. The following articles are recommended for further reading on this topic:

• Bafundo, K.W., et al. Concurrent use of saponins and live coccidiosis vaccines: the influence of a quillaja and yucca combination on anticoccidial effects and performance results of coccidia-vaccinated broilers. Poultry Science, 2021 Mar; 100(3):100905. PMID: 33518338.
• Saeed, Z., et al. Botanicals: A promising approach for controlling cecal coccidiosis in poultry. Frontiers in Veterinary Science, 2023 Apr 25; 10:1157633. PMID: 37180056.

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