Archives

This paper highlights the synergistic potential of combining saponin-based ISCOM adjuvants with immune regulatory modulation, specifically transient depletion of CD25+ regulatory T cells, to [...]

This study evaluates the immunogenicity and protective efficacy of a recombinant H5 hemagglutinin (HA) nanoparticle vaccine adjuvanted with Matrix-M, administered either intranasally or [...]

This paper explores how rapid boosting strategies can significantly enhance germinal center (GC) responses in the context of HIV vaccination, particularly emphasizing the role of saponin-based [...]

This paper uniquely explores how the adjuvant AS01 enhances immune responses in aged populations, focusing on its role in overcoming immunosenescence. By comparing responses to the herpes zoster [...]

This paper presents the design and feasibility considerations for a phase 3 efficacy trial of the M72/AS01E-4 tuberculosis vaccine, which incorporates the AS01 adjuvant system. The primary focus [...]

This paper offers a comprehensive overview of next-generation vaccine adjuvants, with particular emphasis on nanotechnology, systems immunology, and computational approaches. The review [...]

This paper provides a comprehensive overview of advanced nanoparticle-based vaccine platforms, including a focused emphasis on saponin-derived self-assembling nanoplatforms such as ISCOMs and [...]

This paper is a significant contribution to the field of saponin-based adjuvants, particularly highlighting the potent immunostimulatory capacity of the saponin-MPLA nanoparticle adjuvant (SMNP) [...]

This paper presents a comprehensive evaluation of the next-generation liposomal saponin-based adjuvant, ALFQ, in a primate model of HIV-1 vaccination, highlighting its capacity to elicit rapid, [...]