{"id":3957,"date":"2025-11-14T10:53:26","date_gmt":"2025-11-14T13:53:26","guid":{"rendered":"https:\/\/desertking.com\/?p=3957"},"modified":"2025-11-14T10:53:26","modified_gmt":"2025-11-14T13:53:26","slug":"sapn-technology","status":"publish","type":"post","link":"https:\/\/desertking.com\/es\/sapn-technology\/","title":{"rendered":"Belmonte, M., et al. Immunogenicity of HLA-restricted peptide vaccine candidates delivered by self-assembling protein nanoparticle (SAPN) technology. Vaccine, 2025 Oct 12, 66:127832."},"content":{"rendered":"<p><strong>Belmonte, M., et al. Immunogenicity of HLA-restricted peptide vaccine candidates delivered by self-assembling protein nanoparticle (SAPN) technology. <i>Vaccine,<\/i> 2025 Oct 12, 66:127832. PMID: 41082812<\/strong><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Effective long-term vaccines are urgently needed to overcome the parasite\u2019s complexity and reduce the global malaria burden. This study aims to develop and evaluate HLA-restricted peptide vaccines using self-assembling protein nanoparticles (SAPNs) to elicit robust cellular and humoral immunity against malaria.<\/span><\/span>&nbsp;<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">The designed SAPN vaccines, containing conserved and promiscuous HLA-restricted epitopes from P. falciparum antigens, successfully elicited strong cellular immune responses, particularly IFN-\u03b3 producing T cells, and significantly increased antibody titers against sporozoites in transgenic mice. Additionally, the study showed that these epitope-based vaccines can induce multifunctional immune responses, supporting their promise as vaccine candidates for malaria.<\/span><\/span>&nbsp;<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">The paper highlights the crucial role of saponins, such as QS-21, as key components of the ALFQ adjuvant used in SAPN vaccine formulations to enhance immunogenicity. The role of QS-21 is to stimulate and diversify the immune response, promoting stronger antibody and T-cell responses against the vaccine antigens. By incorporating QS-21 into the adjuvant, the authors aimed to improve the efficacy of the vaccine formulations, leveraging saponins&#8217; known ability to activate immune cell pathways and enhance vaccine-induced protection.<\/span><\/span>&nbsp;<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The findings support the feasibility of epitope-based adjuvanted SAPN vaccines as a promising strategy for malaria prevention, leveraging bioinformatics-driven epitope prediction and multiepitope nanoparticle platforms to develop effective, immunogenic, and broadly applicable vaccines<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Click <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41082812\/\" rel=\"nofollow noopener\" target=\"_blank\"><span style=\"font-weight: 400;\">here<\/span><\/a><span style=\"font-weight: 400;\"> to access the full scientific paper.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t\t<style>\r\n\t\t\t\t#sfba_subscribe_form_787 .subscribeform1 {\r\n\t\t\t\t\twidth: 512px;\r\n\t\t\t\t\tborder: 0px solid rgba(0,0,0,0);\r\n\t\t\t\t\tfont-family: 'Verdana';\r\n\t\t\t\t\tbackground-color: #759e2c;\r\n\t\t\t\t\tbackground-image: url('');\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_787 #sfba-main-form-container.subscribeform1 .sfba-form-sub-heading {\r\n\t\t\t\t\tcolor: #102341;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_787 #sfba-main-form-container.subscribeform1 .sfba-form-privacy-heading {\r\n\t\t\t\t\tcolor: ;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_787 #sfba-main-form-container.subscribeform1 .sfba-form-heading {\r\n\t\t\t\t\tcolor: #ffffff;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_787 .subscribeform1 .sfba_subscribe_form__fields .sfba-form-fields {\r\n\t\t\t\t\tborder-color: rgba(0,0,0,0);\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_787 .subscribeform1 .sfba-form-consent-fields-main label,\r\n\t\t\t\t#sfba_subscribe_form_787 .subscribeform1 .sfba-form-consent-fields-main {\r\n\t\t\t\t\tcolor: #ffffff;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_787 .subscribeform1 #sfba-form-button {\r\n\t\t\t\t\tbackground-color: #4c6938;\r\n\t\t\t\t\tcolor: #ffffff;\r\n\t\t\t\t\tfont-size: 14px;\r\n\t\t\t\t}\r\n\t\t\t\t.subscribeform6 #sfba-form-button {\r\n\t\t\t\t\tbackground-image: url(https:\/\/desertking.com\/wp-content\/plugins\/wp-subscribe-forms-pro\/includes\/..\/images\/sent.png);\r\n\t\t\t\t}\r\n\t\t\t\tinput.sfba-form-fields::placeholder { \/ Chrome, Firefox, Opera, Safari 10.1+ \/\r\n\t\t\t\t  color: #7E7E7E;\r\n\t\t\t\t  opacity: 1; 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Immunogenicity of HLA-restricted peptide vaccine candidates delivered by self-assembling protein nanoparticle (SAPN) technology. Vaccine, 2025 Oct 12, 66:127832. PMID: 41082812 Effective long-term vaccines are urgently needed to overcome the parasite\u2019s complexity and reduce the global malaria burden. This study aims to develop and evaluate HLA-restricted peptide vaccines using self-assembling protein nanoparticles [&hellip;]<\/p>\n","protected":false},"author":16,"featured_media":3958,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"rs_blank_template":"","rs_page_bg_color":"","slide_template_v7":"","footnotes":""},"categories":[46],"tags":[],"class_list":["post-3957","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-texto-cientifico"],"_links":{"self":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts\/3957","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/comments?post=3957"}],"version-history":[{"count":0,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts\/3957\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/media\/3958"}],"wp:attachment":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/media?parent=3957"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/categories?post=3957"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/tags?post=3957"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}