{"id":3904,"date":"2025-10-08T17:19:58","date_gmt":"2025-10-08T20:19:58","guid":{"rendered":"https:\/\/desertking.com\/?p=3904"},"modified":"2025-10-08T17:19:58","modified_gmt":"2025-10-08T20:19:58","slug":"chagas-disease-vaccine","status":"publish","type":"post","link":"https:\/\/desertking.com\/es\/chagas-disease-vaccine\/","title":{"rendered":"Zabala, B.A., et al. Induction of Sustained Immunity Following Vaccination with Live Attenuated Trypanosoma cruzi Parasites Combined with Saponin-Based Adjuvants. Biology (Basel), 2025 Sep 20, 14(9):1298."},"content":{"rendered":"<p><strong>Zabala, B.A., et al. Induction of Sustained Immunity Following Vaccination with Live Attenuated Trypanosoma cruzi Parasites Combined with Saponin-Based Adjuvants. <i>Biology (Basel),<\/i> 2025 Sep 20, 14(9):1298. PMID: 41007442<\/strong><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">This study evaluates a vaccine strategy against Chagas disease using live attenuated Trypanosoma cruzi parasites (TCC strain) combined with saponin-based adjuvants (ISPA and Quil-A).\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The findings demonstrate that while all formulations confer strong protection and reduce parasite load in mice, the inclusion of adjuvants enhances immune response regulation, promotes a balanced Th1\/Th2 cytokine profile, and reduces tissue damage and inflammation, thereby improving safety. Specifically, adjuvants support sustained IL-10 production and foster long-term immune memory without parasite persistence, suggesting their potential to optimize vaccine efficacy and safety.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Although a human vaccine remains a future goal, this research provides promising insights for developing safer, more effective veterinary vaccines to control transmission and contribute to broader Chagas disease management strategies.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Click <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41007442\/\" rel=\"nofollow noopener\" target=\"_blank\"><span style=\"font-weight: 400;\">here<\/span><\/a><span style=\"font-weight: 400;\"> to access the full scientific paper.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[arrow_forms id=&#8217;3298&#8242;]<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zabala, B.A., et al. Induction of Sustained Immunity Following Vaccination with Live Attenuated Trypanosoma cruzi Parasites Combined with Saponin-Based Adjuvants. Biology (Basel), 2025 Sep 20, 14(9):1298. PMID: 41007442 This study evaluates a vaccine strategy against Chagas disease using live attenuated Trypanosoma cruzi parasites (TCC strain) combined with saponin-based adjuvants (ISPA and Quil-A).\u00a0 The findings demonstrate [&hellip;]<\/p>\n","protected":false},"author":16,"featured_media":3895,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"rs_blank_template":"","rs_page_bg_color":"","slide_template_v7":"","footnotes":""},"categories":[46],"tags":[],"class_list":["post-3904","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-texto-cientifico"],"_links":{"self":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts\/3904","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/comments?post=3904"}],"version-history":[{"count":0,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts\/3904\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/media\/3895"}],"wp:attachment":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/media?parent=3904"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/categories?post=3904"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/tags?post=3904"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}