{"id":3900,"date":"2025-10-08T17:13:40","date_gmt":"2025-10-08T20:13:40","guid":{"rendered":"https:\/\/desertking.com\/?p=3900"},"modified":"2025-10-08T17:13:40","modified_gmt":"2025-10-08T20:13:40","slug":"delta-v1gp120-alfqa-vaccine-mucosal-immunity","status":"publish","type":"post","link":"https:\/\/desertking.com\/es\/delta-v1gp120-alfqa-vaccine-mucosal-immunity\/","title":{"rendered":"Bissa, M., et al. HIV vaccine candidate \u0394V1gp120 formulated in ALFQA adjuvant augments mucosal immunity in female macaques. Nat Commun, 2025 Sep 29, 16(1):8571."},"content":{"rendered":"<p><strong>Bissa, M., et al. HIV vaccine candidate \u0394V1gp120 formulated in ALFQA adjuvant augments mucosal immunity in female macaques. <i>Nat Commun,<\/i> 2025 Sep 29, 16(1):8571. PMID: 41022728<\/strong><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">This paper explores a new HIV vaccine candidate called \u0394V1gp120 combined with the ALFQA adjuvant that boosts mucosal immunity in female macaques.\u00a0 ALFQA is an advanced liposomal adjuvant formulation incorporating immunostimulatory components (QS-21 and MPLA) that promote both innate and adaptive immunity.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">This study demonstrates that the HIV vaccine candidate \u0394V1gp120 formulated with the ALFQA adjuvant enhances mucosal and systemic immunity in female macaques, providing significant protection against SIV challenge. The adjuvant boosts immune responses by promoting the activation of innate immune cells such as M2-like macrophages, natural killer (NK) cells, and innate lymphoid cells, while also eliciting potent antibody functions like antibody-dependent cellular cytotoxicity (ADCC). These immune enhancements correlate with decreased infection risk, highlighting the importance of both innate and antibody-mediated responses in vaccine efficacy.\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">QS-21 is a key component of the ALFQ adjuvant formulation. QS-21 contributes to the enhancement of immune responses by activating innate immune pathways such as the inflammasome, which promotes robust humoral and cellular immunity. Specifically, the inclusion of QS-21 in ALFQ enhances mucosal immunity and improves vaccine efficacy in the macaque model for HIV, as demonstrated by increased antibody titers and functional immune responses. The paper highlights QS-21\u2019s capacity to stimulate immune cells, including dendritic cells and macrophages, which supports the development of potent protective immunity against HIV\/SIV challenges.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The findings support further development of this vaccine strategy for human trials, emphasizing the potential for adjuvants like ALFQA to induce durable and effective protective immunity against HIV.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Click <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41022728\/\" rel=\"nofollow noopener\" target=\"_blank\"><span style=\"font-weight: 400;\">here<\/span><\/a><span style=\"font-weight: 400;\"> to access the full scientific paper.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t\t<style>\r\n\t\t\t\t#sfba_subscribe_form_927 .subscribeform1 {\r\n\t\t\t\t\twidth: 512px;\r\n\t\t\t\t\tborder: 0px solid rgba(0,0,0,0);\r\n\t\t\t\t\tfont-family: 'Verdana';\r\n\t\t\t\t\tbackground-color: #759e2c;\r\n\t\t\t\t\tbackground-image: url('');\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_927 #sfba-main-form-container.subscribeform1 .sfba-form-sub-heading {\r\n\t\t\t\t\tcolor: #102341;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_927 #sfba-main-form-container.subscribeform1 .sfba-form-privacy-heading {\r\n\t\t\t\t\tcolor: ;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_927 #sfba-main-form-container.subscribeform1 .sfba-form-heading {\r\n\t\t\t\t\tcolor: #ffffff;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_927 .subscribeform1 .sfba_subscribe_form__fields .sfba-form-fields {\r\n\t\t\t\t\tborder-color: rgba(0,0,0,0);\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_927 .subscribeform1 .sfba-form-consent-fields-main label,\r\n\t\t\t\t#sfba_subscribe_form_927 .subscribeform1 .sfba-form-consent-fields-main {\r\n\t\t\t\t\tcolor: #ffffff;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_927 .subscribeform1 #sfba-form-button {\r\n\t\t\t\t\tbackground-color: #4c6938;\r\n\t\t\t\t\tcolor: #ffffff;\r\n\t\t\t\t\tfont-size: 14px;\r\n\t\t\t\t}\r\n\t\t\t\t.subscribeform6 #sfba-form-button {\r\n\t\t\t\t\tbackground-image: url(https:\/\/desertking.com\/wp-content\/plugins\/wp-subscribe-forms-pro\/includes\/..\/images\/sent.png);\r\n\t\t\t\t}\r\n\t\t\t\tinput.sfba-form-fields::placeholder { \/ Chrome, Firefox, Opera, Safari 10.1+ \/\r\n\t\t\t\t  color: #7E7E7E;\r\n\t\t\t\t  opacity: 1; 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HIV vaccine candidate \u0394V1gp120 formulated in ALFQA adjuvant augments mucosal immunity in female macaques. Nat Commun, 2025 Sep 29, 16(1):8571. PMID: 41022728 This paper explores a new HIV vaccine candidate called \u0394V1gp120 combined with the ALFQA adjuvant that boosts mucosal immunity in female macaques.\u00a0 ALFQA is an advanced liposomal adjuvant formulation [&hellip;]<\/p>\n","protected":false},"author":16,"featured_media":3899,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"rs_blank_template":"","rs_page_bg_color":"","slide_template_v7":"","footnotes":""},"categories":[46],"tags":[],"class_list":["post-3900","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-texto-cientifico"],"_links":{"self":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts\/3900","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/comments?post=3900"}],"version-history":[{"count":0,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts\/3900\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/media\/3899"}],"wp:attachment":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/media?parent=3900"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/categories?post=3900"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/tags?post=3900"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}