{"id":3782,"date":"2025-08-08T14:00:37","date_gmt":"2025-08-08T17:00:37","guid":{"rendered":"https:\/\/desertking.com\/?p=3782"},"modified":"2025-08-16T10:47:01","modified_gmt":"2025-08-16T13:47:01","slug":"single-dose-h5n1-nanoparticle-vaccine-primates","status":"publish","type":"post","link":"https:\/\/desertking.com\/es\/single-dose-h5n1-nanoparticle-vaccine-primates\/","title":{"rendered":"Patel, N., et al. Single-dose avian influenza A(H5N1) Clade 2.3.4.4b hemagglutinin-Matrix-M\u00ae nanoparticle vaccine induces neutralizing responses in nonhuman primates. Nat Commun, 2025 Jul 18, 16(1):6625."},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Patel, N., et al. Single-dose avian influenza A(H5N1) Clade 2.3.4.4b hemagglutinin-Matrix-M<\/span><span style=\"font-weight: 400;\">\u00ae<\/span><span style=\"font-weight: 400;\">\u00a0nanoparticle vaccine induces neutralizing responses in nonhuman primates. <\/span><i><span style=\"font-weight: 400;\">Nat Commun<\/span><\/i><span style=\"font-weight: 400;\">, 2025 Jul 18, 16(1):6625. PMID: 40681543<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">This study highlights the role of saponins derived from the Quillaja saponaria Molina tree, which are a key component of the Matrix-M adjuvant used in the H5-MNP vaccine.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The saponins facilitate the formation of cage-like nanoparticle structures by non-covalently anchoring recombinant full-length HA trimers through interactions with lipid and cholesterol components, promoting efficient co-delivery and presentation of antigen. Additionally, the saponins contribute to endosomal disruption within antigen-presenting cells, enabling antigen release into the cytoplasm, thereby enhancing MHC I presentation and inducing robust CD8+ T-cell responses. This dual role of saponins in both nanoparticle assembly and immune activation underscores their importance in augmenting vaccine immunogenicity against H5N1 influenza.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">In conclusion, saponins from Quillaja saponaria Molina are integral to the design and efficacy of the H5-MNP vaccine, serving both as a structural component that facilitates nanoparticle formation through non-covalent anchoring of HA trimers and as an immune stimulator that promotes endosomal disruption and antigen presentation. Their ability to enhance both humoral and cellular immune responses, including CD8+ T-cell activation, underscores their vital role in advancing effective influenza vaccines against emerging HPAI strains. This dual functionality demonstrates the potential of saponins as powerful adjuvants in next-generation vaccine formulations.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Click <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40681543\/\" target=\"_blank\" rel=\"noopener nofollow\"><span style=\"font-weight: 400;\">here<\/span><\/a><span style=\"font-weight: 400;\"> to access the full scientific paper.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[arrow_forms id=&#8217;3298&#8242;]<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Patel, N., et al. Single-dose avian influenza A(H5N1) Clade 2.3.4.4b hemagglutinin-Matrix-M\u00ae\u00a0nanoparticle vaccine induces neutralizing responses in nonhuman primates. Nat Commun, 2025 Jul 18, 16(1):6625. PMID: 40681543 This study highlights the role of saponins derived from the Quillaja saponaria Molina tree, which are a key component of the Matrix-M adjuvant used in the H5-MNP vaccine.\u00a0 The [&hellip;]<\/p>\n","protected":false},"author":16,"featured_media":3781,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"rs_blank_template":"","rs_page_bg_color":"","slide_template_v7":"","footnotes":""},"categories":[46],"tags":[],"class_list":["post-3782","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-texto-cientifico"],"_links":{"self":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts\/3782","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/comments?post=3782"}],"version-history":[{"count":0,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts\/3782\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/media\/3781"}],"wp:attachment":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/media?parent=3782"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/categories?post=3782"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/tags?post=3782"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}