{"id":3776,"date":"2025-08-08T13:52:41","date_gmt":"2025-08-08T16:52:41","guid":{"rendered":"https:\/\/desertking.com\/?p=3776"},"modified":"2025-08-17T10:22:46","modified_gmt":"2025-08-17T13:22:46","slug":"sars-cov-2-rbd-protein-vaccine-macaques","status":"publish","type":"post","link":"https:\/\/desertking.com\/es\/sars-cov-2-rbd-protein-vaccine-macaques\/","title":{"rendered":"Scaria, P.V., et al. SARS-CoV-2 Receptor Binding Domain (RBD) Protein-Protein Conjugate Induces Similar or Better Antibody Responses as Spike mRNA in Rhesus Macaques. Vaccines (Basel), 2025 Jun 17, 13(6):648."},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Scaria, P.V., et al. SARS-CoV-2 Receptor Binding Domain (RBD) Protein-Protein Conjugate Induces Similar or Better Antibody Responses as Spike mRNA in Rhesus Macaques. <\/span><i><span style=\"font-weight: 400;\">Vaccines (Basel)<\/span><\/i><span style=\"font-weight: 400;\">, 2025 Jun 17, 13(6):648. PMID: 40573979<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">This study demonstrates that an RBD-EcoCRM conjugate vaccine adjuvanted with AS01 can induce robust, high-quality antibody responses in rhesus macaques that are comparable or superior to those elicited by the approved mRNA COVID-19 vaccine (Pfizer\/BioNTech BNT162b2).\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The conjugate vaccine elicited strong binding, neutralizing, and inhibiting antibodies against the virus and its variants, with immune responses persisting for at least six months post-vaccination. The conjugate vaccine with AS01 adjuvant produced higher or similar levels of serum antibodies, virus neutralization activity, and binding inhibition against SARS-CoV-2 variants. Additionally, the conjugate vaccine elicited antibody responses against both the RBD and full-length Spike proteins, with some indications of broader epitope recognition, which might contribute to its efficacy.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">One notable aspect is the durability of the immune response; the antibody levels and neutralization activity, although waning over time, remained higher or comparable in the conjugate group relative to the mRNA group at later time points, such as 6 months post-vaccination. Furthermore, the subclass profile of antibodies induced by the conjugate vaccine (more IgG2 and IgG4 over time) and the natural waning of antibody levels may influence the long-term protection differently.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Importantly, the potential advantages include better safety profiles, easier manufacturing, stability, and adaptability to viral evolution, making the AS01b-adjuvanted conjugate vaccine a promising alternative, especially in settings where mRNA vaccines might pose logistical challenges or have safety concerns. The conjugate vaccines are effective, scalable, and possibly more accessible alternatives for COVID-19 immunization, especially in low- and middle-income settings. However, direct head-to-head comparative efficacy data in humans would be necessary for definitive conclusions.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Click <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40573979\/\" rel=\"nofollow noopener\" target=\"_blank\"><span style=\"font-weight: 400;\">here<\/span><\/a><span style=\"font-weight: 400;\"> to access the full scientific paper.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">[arrow_forms id=&#8217;3298&#8242;]<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scaria, P.V., et al. SARS-CoV-2 Receptor Binding Domain (RBD) Protein-Protein Conjugate Induces Similar or Better Antibody Responses as Spike mRNA in Rhesus Macaques. Vaccines (Basel), 2025 Jun 17, 13(6):648. PMID: 40573979 This study demonstrates that an RBD-EcoCRM conjugate vaccine adjuvanted with AS01 can induce robust, high-quality antibody responses in rhesus macaques that are comparable or [&hellip;]<\/p>\n","protected":false},"author":16,"featured_media":3775,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"rs_blank_template":"","rs_page_bg_color":"","slide_template_v7":"","footnotes":""},"categories":[46],"tags":[],"class_list":["post-3776","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-texto-cientifico"],"_links":{"self":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts\/3776","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/comments?post=3776"}],"version-history":[{"count":0,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts\/3776\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/media\/3775"}],"wp:attachment":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/media?parent=3776"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/categories?post=3776"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/tags?post=3776"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}