{"id":3772,"date":"2025-08-08T13:36:35","date_gmt":"2025-08-08T16:36:35","guid":{"rendered":"https:\/\/desertking.com\/dagnew-a-f-et-al-safety-and-immunogenicity-of-investigational-tuberculosis-vaccine-m72-as01e4-in-people-living-with-hiv-in-south-africa-an-observer-blinded-randomised-controlled-phase-2-trial\/"},"modified":"2025-09-10T18:26:28","modified_gmt":"2025-09-10T21:26:28","slug":"tuberculosis-vaccine-saponin-adjuvant-hiv-trial","status":"publish","type":"post","link":"https:\/\/desertking.com\/es\/tuberculosis-vaccine-saponin-adjuvant-hiv-trial\/","title":{"rendered":"Dagnew, A.F., et al. Safety and immunogenicity of investigational tuberculosis vaccine M72\/AS01E4 in people living with HIV in South Africa: an observer-blinded, randomised, controlled, phase 2 trial. Lancet HIV, 2025 Aug, 12(8):e546-e555."},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Dagnew, A.F., et al. Safety and immunogenicity of investigational tuberculosis vaccine M72\/AS01<\/span><span style=\"font-weight: 400;\">E4<\/span><span style=\"font-weight: 400;\">\u00a0in people living with HIV in South Africa: an observer-blinded, randomised, controlled, phase 2 trial. <\/span><i><span style=\"font-weight: 400;\">Lancet HIV<\/span><\/i><span style=\"font-weight: 400;\">, 2025 Aug, 12(8):e546-e555. PMID: 40614747<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The study evaluated the safety, reactogenicity, and immunogenicity of two doses of the TB vaccine M72\/AS01 E\u20134 in over 400 HIV-positive adults in South Africa with well-controlled, virally suppressed HIV.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The vaccine was well tolerated, with mostly mild or moderate side effects such as injection-site pain, headache, and fatigue, and showed no serious adverse events related to vaccination. Importantly, it elicited strong antibody and T-cell responses, indicating a robust immune response, which was sustained through the end of the trial.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The paper describes QS-21 as a key component of the AS01 E\u20134 adjuvant system used in the M72\/AS01 E\u20134 tuberculosis vaccine. QS-21 is a saponin extract derived from Quillaja saponaria Molina, included at a dose of 25 \u03bcg per vaccine dose. The study reports that the vaccine, which contains QS-21, elicited robust antibody and CD4 T-cell responses, indicating that QS-21 contributes significantly to the vaccine\u2019s immunogenic profile. Additionally, the safety data suggest that inclusion of QS-21 does not compromise tolerability, as most adverse events were mild or moderate and transient.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">These findings support further testing of the vaccine in larger populations, including people living with HIV, to assess its effectiveness in preventing tuberculosis in this high-risk group.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Click <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40614747\/\" rel=\"nofollow noopener\" target=\"_blank\"><span style=\"font-weight: 400;\">here <\/span><\/a><span style=\"font-weight: 400;\">to access the full scientific paper.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t\t<style>\r\n\t\t\t\t#sfba_subscribe_form_842 .subscribeform1 {\r\n\t\t\t\t\twidth: 512px;\r\n\t\t\t\t\tborder: 0px solid rgba(0,0,0,0);\r\n\t\t\t\t\tfont-family: 'Verdana';\r\n\t\t\t\t\tbackground-color: #759e2c;\r\n\t\t\t\t\tbackground-image: url('');\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_842 #sfba-main-form-container.subscribeform1 .sfba-form-sub-heading {\r\n\t\t\t\t\tcolor: #102341;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_842 #sfba-main-form-container.subscribeform1 .sfba-form-privacy-heading {\r\n\t\t\t\t\tcolor: ;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_842 #sfba-main-form-container.subscribeform1 .sfba-form-heading {\r\n\t\t\t\t\tcolor: #ffffff;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_842 .subscribeform1 .sfba_subscribe_form__fields .sfba-form-fields {\r\n\t\t\t\t\tborder-color: rgba(0,0,0,0);\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_842 .subscribeform1 .sfba-form-consent-fields-main label,\r\n\t\t\t\t#sfba_subscribe_form_842 .subscribeform1 .sfba-form-consent-fields-main {\r\n\t\t\t\t\tcolor: #ffffff;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_842 .subscribeform1 #sfba-form-button {\r\n\t\t\t\t\tbackground-color: #4c6938;\r\n\t\t\t\t\tcolor: #ffffff;\r\n\t\t\t\t\tfont-size: 14px;\r\n\t\t\t\t}\r\n\t\t\t\t.subscribeform6 #sfba-form-button {\r\n\t\t\t\t\tbackground-image: url(https:\/\/desertking.com\/wp-content\/plugins\/wp-subscribe-forms-pro\/includes\/..\/images\/sent.png);\r\n\t\t\t\t}\r\n\t\t\t\tinput.sfba-form-fields::placeholder { \/ Chrome, Firefox, Opera, Safari 10.1+ \/\r\n\t\t\t\t  color: #7E7E7E;\r\n\t\t\t\t  opacity: 1; 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Safety and immunogenicity of investigational tuberculosis vaccine M72\/AS01E4\u00a0in people living with HIV in South Africa: an observer-blinded, randomised, controlled, phase 2 trial. Lancet HIV, 2025 Aug, 12(8):e546-e555. PMID: 40614747 The study evaluated the safety, reactogenicity, and immunogenicity of two doses of the TB vaccine M72\/AS01 E\u20134 in over 400 HIV-positive adults [&hellip;]<\/p>\n","protected":false},"author":16,"featured_media":3770,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"rs_blank_template":"","rs_page_bg_color":"","slide_template_v7":"","footnotes":""},"categories":[46],"tags":[],"class_list":["post-3772","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-texto-cientifico"],"_links":{"self":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts\/3772","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/comments?post=3772"}],"version-history":[{"count":0,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts\/3772\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/media\/3770"}],"wp:attachment":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/media?parent=3772"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/categories?post=3772"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/tags?post=3772"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}