{"id":3580,"date":"2025-05-15T11:44:33","date_gmt":"2025-05-15T14:44:33","guid":{"rendered":"https:\/\/desertkingdev.wpenginepowered.com\/haine-v-et-al-safety-of-rtss-as01e-malaria-vaccine-up-to-1-year-after-the-third-dose-in-ghana-kenya-and-malawi-epi-mal-003-a-phase-4-cohort-event-monitoring-study\/"},"modified":"2025-05-15T11:44:33","modified_gmt":"2025-05-15T14:44:33","slug":"haine-v-et-al-safety-of-rtss-as01e-malaria-vaccine-up-to-1-year-after-the-third-dose-in-ghana-kenya-and-malawi-epi-mal-003-a-phase-4-cohort-event-monitoring-study","status":"publish","type":"post","link":"https:\/\/desertking.com\/es\/haine-v-et-al-safety-of-rtss-as01e-malaria-vaccine-up-to-1-year-after-the-third-dose-in-ghana-kenya-and-malawi-epi-mal-003-a-phase-4-cohort-event-monitoring-study\/","title":{"rendered":"Haine, V., et al. Safety of RTS,S\/AS01E malaria vaccine up to 1 year after the third dose in Ghana, Kenya, and Malawi (EPI-MAL-003): a phase 4 cohort event monitoring study."},"content":{"rendered":"<p><strong>Haine, V., et al. Safety of RTS,S\/AS01E malaria vaccine up to 1 year after the third dose in Ghana, Kenya, and Malawi (EPI-MAL-003): a phase 4 cohort event monitoring study.   <\/strong><\/p>\n<p><strong>Lancet Glob Health, 2025 Abr 24, S2214-109X(25)00096-8.  <span class=\"TextRun SCXW113834958 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW113834958 BCX0\">PMID: 40288377<\/span><\/span><\/strong><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{\"335551500\":0,\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">El EPI-MAL-003  <\/span><span data-contrast=\"auto\">eval\u00faa la seguridad y eficacia de la vacuna antipal\u00fadica RTS,S\/AS01 en entornos reales de Ghana, Kenia y Malawi, un a\u00f1o despu\u00e9s de la administraci\u00f3n de la tercera dosis a trav\u00e9s del Programa de Aplicaci\u00f3n de la Vacuna Antipal\u00fadica (MVIP). Incluy\u00f3 un an\u00e1lisis de 44.912 ni\u00f1os y emple\u00f3 sistemas mejorados de vigilancia y seguimiento de los eventos de seguridad, centr\u00e1ndose especialmente en la meningitis, la malaria cerebral y las tasas de mortalidad.   <\/span><span data-ccp-props=\"{\"134233279\":false,\"201341983\":0,\"335551550\":6,\"335551620\":6,\"335559739\":120,\"335559740\":240}\"> <\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{\"335551500\":0,\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Se ha demostrado que la vacuna RTS,S\/AS01 proporciona una eficacia significativa en la reducci\u00f3n de la incidencia de la malaria entre los ni\u00f1os peque\u00f1os. En ensayos pivotales de fase 3, la vacuna demostr\u00f3 una eficacia de aproximadamente el 51% contra el paludismo cl\u00ednico durante los 12 meses siguientes a la tercera dosis y una eficacia media del 36% durante un periodo de seguimiento m\u00e1s largo de 48 meses, evitando una media de 1.774 casos de paludismo cl\u00ednico por cada 1.000 ni\u00f1os vacunados. <\/span><span data-ccp-props=\"{\"134233279\":false,\"201341983\":0,\"335551550\":6,\"335551620\":6,\"335559739\":120,\"335559740\":240}\"> <\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{\"335551500\":0,\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\">Este estudio es el mayor estudio observacional realizado hasta la fecha sobre los resultados de la vacunaci\u00f3n antipal\u00fadica, en el que se constat\u00f3 una elevada cobertura vacunal y ninguna prueba de aumento de los riesgos de seguridad. Los resultados indican un perfil de seguridad favorable para RTS,S\/AS01E. La vacuna RTS,S a\u00f1ade un enfoque complementario a las estrategias de control de la malaria y, por lo tanto, en regiones con una transmisi\u00f3n de moderada a alta de Plasmodium falciparum, la vacuna RTS,S est\u00e1 destinada a servir como herramienta adicional junto con los mosquiteros tratados con insecticida (ITN) y los m\u00e9todos convencionales de fumigaci\u00f3n de interiores con efecto residual (IRS). Los datos sugieren que la vacuna RTS,S\/AS01 no s\u00f3lo sigue siendo segura, sino que tambi\u00e9n contribuye a reducir las muertes relacionadas con la malaria en las regiones end\u00e9micas, lo que respalda su uso continuado en ni\u00f1os peque\u00f1os.   <\/span><span data-ccp-props=\"{\"134233279\":false,\"201341983\":0,\"335551550\":6,\"335551620\":6,\"335559739\":120,\"335559740\":240}\"> <\/span><\/li>\n<\/ul>\n<p>Haz clic <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40288377\/\" target=\"_blank\" rel=\"noopener nofollow\">aqu\u00ed <\/a>para acceder al art\u00edculo cient\u00edfico completo.<\/p>\n<p>&nbsp;<\/p>\n\t\t\t<style>\r\n\t\t\t\t#sfba_subscribe_form_729 .subscribeform1 {\r\n\t\t\t\t\twidth: 514px;\r\n\t\t\t\t\tborder: 0px groove rgba(159,51,221,0);\r\n\t\t\t\t\tfont-family: 'Verdana';\r\n\t\t\t\t\tbackground-color: #759e2c;\r\n\t\t\t\t\tbackground-image: url('');\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_729 #sfba-main-form-container.subscribeform1 .sfba-form-sub-heading {\r\n\t\t\t\t\tcolor: #000000;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_729 #sfba-main-form-container.subscribeform1 .sfba-form-privacy-heading {\r\n\t\t\t\t\tcolor: ;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_729 #sfba-main-form-container.subscribeform1 .sfba-form-heading {\r\n\t\t\t\t\tcolor: #ffffff;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_729 .subscribeform1 .sfba_subscribe_form__fields .sfba-form-fields {\r\n\t\t\t\t\tborder-color: rgba(0,0,0,0);\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_729 .subscribeform1 .sfba-form-consent-fields-main label,\r\n\t\t\t\t#sfba_subscribe_form_729 .subscribeform1 .sfba-form-consent-fields-main {\r\n\t\t\t\t\tcolor: #ffffff;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_729 .subscribeform1 #sfba-form-button {\r\n\t\t\t\t\tbackground-color: #4c6938;\r\n\t\t\t\t\tcolor: #ffffff;\r\n\t\t\t\t\tfont-size: 14px;\r\n\t\t\t\t}\r\n\t\t\t\t.subscribeform6 #sfba-form-button {\r\n\t\t\t\t\tbackground-image: url(https:\/\/desertking.com\/wp-content\/plugins\/wp-subscribe-forms-pro\/includes\/..\/images\/sent.png);\r\n\t\t\t\t}\r\n\t\t\t\tinput.sfba-form-fields::placeholder { \/ Chrome, Firefox, Opera, Safari 10.1+ \/\r\n\t\t\t\t  color: #7E7E7E;\r\n\t\t\t\t  opacity: 1; 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color:#ff0606;\">Por favor selecciona la opci\u00f3n \"Estoy de acuerdo con recibir notificaciones por correo\"<\/p>\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"sfba-email-field-error error\" style=\"display:none !important; color:#ff0606;\">El campo de correo electr\u00f3nico es obligatorio para suscribirse.<\/p>\r\n\t\t\t\t\t\t\t\t\t\t\t\t<input type=\"submit\" id=\"sfba-form-button\" class=\"sfba-form-submit-button subscribeform1_subscribe_btn\" data-form-id=\"subscribeform1\" data-rand-id=\"sfba_subscribe_form_729\" value=\"Registrarse\" \/>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t\t\t<div id=\"sfba_thanks_container\" class=\"sfba_thanks_container\" style=\"display: none;\">\r\n\t\t\t\t\t\t<a href=\"javascript:void(0);\" class=\"sfba-form-close\" data-form-id=\"sfba_subscribe_form_729\">x<\/a>\r\n\t\t\t\t\t\t<div class=\"sfba-thanks-wrap\">\r\n\t\t\t\t\t\t\t<p id=\"sfba_thanks_image\" class=\"sfba-noempty\">\r\n\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/desertking.com\/wp-content\/uploads\/2025\/03\/tick.png\" \/>\r\n\t\t\t\t\t\t\t<\/p>\r\n\t\t\t\t\t\t\t<p id=\"sfba_thanks_message\" class=\"subscribeform1_thanks_message\">Te has suscrito exitosamente a Saponin Science Spotlight<\/p>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\t\r\n\t\t\t\t<\/div>\r\n\t\t\t\t<input type=\"hidden\" id=\"sfba_page_link\" class=\"sfba_page_link\" name=\"sfba-page-link\" value=\"https:\/\/desertking.com\/es\/haine-v-et-al-safety-of-rtss-as01e-malaria-vaccine-up-to-1-year-after-the-third-dose-in-ghana-kenya-and-malawi-epi-mal-003-a-phase-4-cohort-event-monitoring-study\/\" \/>\r\n\t\t\t\t<input type='hidden' id='sfba_post_type_id' class=\"sfba_post_type_id\" name=\"sfba_post_type_id\" value=\"3319\" \/> \r\n\t\t\t\t\t\t\t<\/form>\r\n\t\t\t\n","protected":false},"excerpt":{"rendered":"<p>Haine, V., et al. Safety of RTS,S\/AS01E malaria vaccine up to 1 year after the third dose in Ghana, Kenya, and Malawi (EPI-MAL-003): a phase 4 cohort event monitoring study. Lancet Glob Health, 2025 Abr 24, S2214-109X(25)00096-8. PMID: 40288377 El EPI-MAL-003 eval\u00faa la seguridad y eficacia de la vacuna antipal\u00fadica RTS,S\/AS01 en entornos reales de [&hellip;]<\/p>\n","protected":false},"author":16,"featured_media":3502,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"rs_blank_template":"","rs_page_bg_color":"","slide_template_v7":"","footnotes":""},"categories":[46],"tags":[],"class_list":["post-3580","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-texto-cientifico"],"_links":{"self":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts\/3580","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/comments?post=3580"}],"version-history":[{"count":0,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts\/3580\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/media\/3502"}],"wp:attachment":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/media?parent=3580"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/categories?post=3580"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/tags?post=3580"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}