{"id":3578,"date":"2025-05-09T12:49:43","date_gmt":"2025-05-09T15:49:43","guid":{"rendered":"https:\/\/desertkingdev.wpenginepowered.com\/ison-m-g-et-al-eficacia-seguridad-e-inmunogenicidad-de-la-vacuna-de-proteina-f-de-prefusion-del-virus-respiratorio-sincitial-adyuvada-con-as01e-rsvpref3-oa-en-adultos-mayores-durante-tres-tempo\/"},"modified":"2025-09-11T13:30:18","modified_gmt":"2025-09-11T16:30:18","slug":"rsv-vaccine-efficacy-older-adults-three-seasons","status":"publish","type":"post","link":"https:\/\/desertking.com\/es\/rsv-vaccine-efficacy-older-adults-three-seasons\/","title":{"rendered":"Ison, M.G., et al. Efficacy, safety, and immunogenicity of the AS01E-adjuvanted respiratory syncytial virus prefusion F protein vaccine (RSVPreF3 OA) in older adults over three respiratory syncytial virus seasons (AReSVi-006): a multicentre, randomised, observer-blinded, placebo-controlled, phase 3 trial."},"content":{"rendered":"<p><strong><span class=\"TextRun SCXW113750996 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW113750996 BCX0\">I<\/span><span class=\"NormalTextRun SCXW113750996 BCX0\">son<\/span><span class=\"NormalTextRun SCXW113750996 BCX0\">,<\/span><span class=\"NormalTextRun SCXW113750996 BCX0\"> M<\/span><span class=\"NormalTextRun SCXW113750996 BCX0\">.<\/span><span class=\"NormalTextRun SCXW113750996 BCX0\">G<\/span><span class=\"NormalTextRun SCXW113750996 BCX0\">.<\/span><span class=\"NormalTextRun SCXW113750996 BCX0\">,<\/span><span class=\"NormalTextRun SCXW113750996 BCX0\"> et al.<\/span><span class=\"NormalTextRun SCXW113750996 BCX0\"> Efficacy, safety, and immunogenicity of the AS01<\/span><\/span><span class=\"TextRun SCXW113750996 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun Subscript SCXW113750996 BCX0\" data-fontsize=\"11\">E<\/span><\/span><span class=\"TextRun SCXW113750996 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW113750996 BCX0\">-adjuvanted respiratory syncytial virus prefusion F protein vaccine (RSVPreF3 OA) in older adults over three respiratory syncytial virus seasons (AReSVi-006): a <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW113750996 BCX0\">multicentre<\/span><span class=\"NormalTextRun SCXW113750996 BCX0\">, <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW113750996 BCX0\">randomised<\/span><span class=\"NormalTextRun SCXW113750996 BCX0\">, observer-blinded, placebo-controlled, phase 3 trial.<\/span><\/span><\/strong><\/p>\n<p><strong><span class=\"TextRun SCXW113750996 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW113750996 BCX0\">Lancet Respir Med<\/span><\/span><span class=\"TextRun SCXW113750996 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW113750996 BCX0\">,<\/span><span class=\"NormalTextRun SCXW113750996 BCX0\"> 2025 Apr 11<\/span><span class=\"NormalTextRun SCXW113750996 BCX0\">, <\/span><span class=\"NormalTextRun SCXW113750996 BCX0\">S2213-2600(25)00048-7. <span class=\"NormalTextRun SCXW26399953 BCX0\">PMID: 40245915<\/span>\u00a0<\/span><\/span><\/strong><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"6\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:1440,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">This study evaluates the efficacy, safety, and immunogenicity of the AS01<\/span><span data-contrast=\"none\">E<\/span><span data-contrast=\"none\">-adjuvanted RSV prefusion F protein vaccine in older adults over three RSV seasons. The research focuses on how well the vaccine protects against RSV-related lower respiratory tract disease, particularly in individuals aged 60 and older.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559685&quot;:720,&quot;335559739&quot;:120,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"6\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:1440,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"none\">The exposed population included 24,972 participants: 12,469 received RSVPreF3 OA and 12,503 received placebo before RSV season one. The cumulative efficacy of a single RSVPreF3 OA dose in preventing RSV-LRTD over three RSV seasons was 62.9% (97.5% CI 46.7\u201374.8). Between dose one and trial end, eight (&lt;1%) participants in the RSV single-dose group, 12 (&lt;1%) in the RSV revaccination group, and 12 (&lt;1%) in the placebo group had a serious adverse event.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559685&quot;:720,&quot;335559739&quot;:120,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"6\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:1440,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"none\">Comment:<\/span> <span data-contrast=\"none\">While the paper discusses that the AS01<\/span><span data-contrast=\"none\">E<\/span><span data-contrast=\"none\"> adjuvant is used with the RSVPreF3 OA vaccine to enhance the immune response to the RSV fusion (F) protein, the paper does not provide definitive evidence linking the adjuvant directly to the level of efficacy observed.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559685&quot;:720,&quot;335559739&quot;:120,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<p>Click\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40245915\/\" target=\"_blank\" rel=\"noopener nofollow\">here<\/a>\u00a0to access the full scientific paper.<\/p>\n<p>&nbsp;<\/p>\n\t\t\t<style>\r\n\t\t\t\t#sfba_subscribe_form_938 .subscribeform1 {\r\n\t\t\t\t\twidth: 512px;\r\n\t\t\t\t\tborder: 0px solid rgba(0,0,0,0);\r\n\t\t\t\t\tfont-family: 'Verdana';\r\n\t\t\t\t\tbackground-color: #759e2c;\r\n\t\t\t\t\tbackground-image: url('');\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_938 #sfba-main-form-container.subscribeform1 .sfba-form-sub-heading {\r\n\t\t\t\t\tcolor: #102341;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_938 #sfba-main-form-container.subscribeform1 .sfba-form-privacy-heading {\r\n\t\t\t\t\tcolor: ;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_938 #sfba-main-form-container.subscribeform1 .sfba-form-heading {\r\n\t\t\t\t\tcolor: #ffffff;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_938 .subscribeform1 .sfba_subscribe_form__fields .sfba-form-fields {\r\n\t\t\t\t\tborder-color: rgba(0,0,0,0);\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_938 .subscribeform1 .sfba-form-consent-fields-main label,\r\n\t\t\t\t#sfba_subscribe_form_938 .subscribeform1 .sfba-form-consent-fields-main {\r\n\t\t\t\t\tcolor: #ffffff;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_938 .subscribeform1 #sfba-form-button {\r\n\t\t\t\t\tbackground-color: #4c6938;\r\n\t\t\t\t\tcolor: #ffffff;\r\n\t\t\t\t\tfont-size: 14px;\r\n\t\t\t\t}\r\n\t\t\t\t.subscribeform6 #sfba-form-button {\r\n\t\t\t\t\tbackground-image: url(https:\/\/desertking.com\/wp-content\/plugins\/wp-subscribe-forms-pro\/includes\/..\/images\/sent.png);\r\n\t\t\t\t}\r\n\t\t\t\tinput.sfba-form-fields::placeholder { \/ Chrome, Firefox, Opera, Safari 10.1+ \/\r\n\t\t\t\t  color: #7E7E7E;\r\n\t\t\t\t  opacity: 1; 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Efficacy, safety, and immunogenicity of the AS01E-adjuvanted respiratory syncytial virus prefusion F protein vaccine (RSVPreF3 OA) in older adults over three respiratory syncytial virus seasons (AReSVi-006): a multicentre, randomised, observer-blinded, placebo-controlled, phase 3 trial. Lancet Respir Med, 2025 Apr 11, S2213-2600(25)00048-7. PMID: 40245915\u00a0 This study evaluates the efficacy, safety, and immunogenicity [&hellip;]<\/p>\n","protected":false},"author":16,"featured_media":3508,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"rs_blank_template":"","rs_page_bg_color":"","slide_template_v7":"","footnotes":""},"categories":[46],"tags":[],"class_list":["post-3578","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-texto-cientifico"],"_links":{"self":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts\/3578","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/comments?post=3578"}],"version-history":[{"count":0,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts\/3578\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/media\/3508"}],"wp:attachment":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/media?parent=3578"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/categories?post=3578"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/tags?post=3578"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}