{"id":3567,"date":"2025-05-09T13:25:41","date_gmt":"2025-05-09T16:25:41","guid":{"rendered":"https:\/\/desertkingdev.wpenginepowered.com\/song-y-et-al-reduccion-de-50-veces-la-dosis-de-adyuvante-y-20-veces-la-dosis-de-antigeno-vacunal-a-partir-de-la-visualizacion-en-nanoliposomas-de-un-antigeno-proteico-estabilizado-de-la-malaria\/"},"modified":"2025-09-11T13:06:00","modified_gmt":"2025-09-11T16:06:00","slug":"nanoliposome-vaccine-antigen-dose-sparing-malaria","status":"publish","type":"post","link":"https:\/\/desertking.com\/es\/nanoliposome-vaccine-antigen-dose-sparing-malaria\/","title":{"rendered":"Song, Y., et al.  50-Fold Adjuvant and 20-Fold Antigen Vaccine Dose Sparing from Nanoliposome Display of a Stabilized Malarial Protein Antigen."},"content":{"rendered":"<p><strong><span class=\"NormalTextRun SCXW239428980 BCX0\">Song, Y., <\/span><span class=\"NormalTextRun SCXW239428980 BCX0\">et al.\u00a0 <\/span><span class=\"NormalTextRun SCXW239428980 BCX0\">50-Fold Adjuvant and 20-Fold Antigen Vaccine Dose Sparing from Nanoliposome Display of a Stabilized Malarial Protein Antigen.<\/span><\/strong><\/p>\n<p><strong><span class=\"TextRun SCXW239428980 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW239428980 BCX0\">CS Nano<\/span><\/span><span class=\"TextRun SCXW239428980 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW239428980 BCX0\">, 2025 Mar 18, 19(10):10103-10112. PMID: 40099532<\/span><\/span><\/strong><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"10\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">The study investigates the use of nanoliposomes to enhance the immunogenicity of a stabilized malarial protein antigen, Pfs48\/45, focusing on antigen and adjuvant dose sparing.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:120,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"10\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">While both MPLA and QS-21 contributed positively to the vaccine&#8217;s performance, the effectiveness of the complete formulation with both immune modulators combined in the liposomal formulation, along with the cobalt porphyrin phospholipid (CoPoP), was emphasized as the best in terms of eliciting a robust immune response with substantial dose-sparing advantages. By displaying the antigen on CoPoP liposomes, the research demonstrated a significant 50-fold reduction in the required adjuvant doses and a 20-fold reduction in the antigen doses while still eliciting strong antibody responses in mice. This liposome-bound format allowed for superior antibody titers compared to soluble forms, supporting the potential of this approach for the development of more effective and cost-efficient malaria vaccines.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:120,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"10\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\">The results emphasize the importance of nanoparticle-based vaccine strategies in improving immunogenicity and enabling scalable production for future vaccine deployment.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:120,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><span class=\"TextRun SCXW11096219 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW11096219 BCX0\">Click\u00a0<\/span><span class=\"NormalTextRun SCXW11096219 BCX0\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40099532\/\" target=\"_blank\" rel=\"noopener nofollow\">here<\/a>\u00a0<\/span><span class=\"NormalTextRun SCXW11096219 BCX0\">to access the full scientific paper.<\/span><\/span><span class=\"EOP SCXW11096219 BCX0\" data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:120,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n\t\t\t<style>\r\n\t\t\t\t#sfba_subscribe_form_63 .subscribeform1 {\r\n\t\t\t\t\twidth: 512px;\r\n\t\t\t\t\tborder: 0px solid rgba(0,0,0,0);\r\n\t\t\t\t\tfont-family: 'Verdana';\r\n\t\t\t\t\tbackground-color: #759e2c;\r\n\t\t\t\t\tbackground-image: url('');\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_63 #sfba-main-form-container.subscribeform1 .sfba-form-sub-heading {\r\n\t\t\t\t\tcolor: #102341;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_63 #sfba-main-form-container.subscribeform1 .sfba-form-privacy-heading {\r\n\t\t\t\t\tcolor: ;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_63 #sfba-main-form-container.subscribeform1 .sfba-form-heading {\r\n\t\t\t\t\tcolor: #ffffff;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_63 .subscribeform1 .sfba_subscribe_form__fields .sfba-form-fields {\r\n\t\t\t\t\tborder-color: rgba(0,0,0,0);\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_63 .subscribeform1 .sfba-form-consent-fields-main label,\r\n\t\t\t\t#sfba_subscribe_form_63 .subscribeform1 .sfba-form-consent-fields-main {\r\n\t\t\t\t\tcolor: #ffffff;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_63 .subscribeform1 #sfba-form-button {\r\n\t\t\t\t\tbackground-color: #4c6938;\r\n\t\t\t\t\tcolor: #ffffff;\r\n\t\t\t\t\tfont-size: 14px;\r\n\t\t\t\t}\r\n\t\t\t\t.subscribeform6 #sfba-form-button {\r\n\t\t\t\t\tbackground-image: url(https:\/\/desertking.com\/wp-content\/plugins\/wp-subscribe-forms-pro\/includes\/..\/images\/sent.png);\r\n\t\t\t\t}\r\n\t\t\t\tinput.sfba-form-fields::placeholder { \/ Chrome, Firefox, Opera, Safari 10.1+ \/\r\n\t\t\t\t  color: #7E7E7E;\r\n\t\t\t\t  opacity: 1; 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CS Nano, 2025 Mar 18, 19(10):10103-10112. PMID: 40099532 The study investigates the use of nanoliposomes to enhance the immunogenicity of a stabilized malarial protein antigen, Pfs48\/45, focusing on antigen and adjuvant dose sparing.\u00a0\u00a0 While [&hellip;]<\/p>\n","protected":false},"author":16,"featured_media":3525,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"rs_blank_template":"","rs_page_bg_color":"","slide_template_v7":"","footnotes":""},"categories":[46],"tags":[],"class_list":["post-3567","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-texto-cientifico"],"_links":{"self":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts\/3567","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/comments?post=3567"}],"version-history":[{"count":0,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts\/3567\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/media\/3525"}],"wp:attachment":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/media?parent=3567"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/categories?post=3567"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/tags?post=3567"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}