{"id":3454,"date":"2025-04-25T16:39:18","date_gmt":"2025-04-25T19:39:18","guid":{"rendered":"https:\/\/desertkingdev.wpenginepowered.com\/gonzalez-h-l-d-m-et-al-eficacia-de-la-vacuna-laag-asociada-a-saponina-contra-la-infeccion-por-leishmania-amazonensis\/"},"modified":"2025-05-14T12:38:30","modified_gmt":"2025-05-14T15:38:30","slug":"gonzalez-h-l-d-m-et-al-eficacia-de-la-vacuna-laag-asociada-a-saponina-contra-la-infeccion-por-leishmania-amazonensis","status":"publish","type":"post","link":"https:\/\/desertking.com\/es\/gonzalez-h-l-d-m-et-al-eficacia-de-la-vacuna-laag-asociada-a-saponina-contra-la-infeccion-por-leishmania-amazonensis\/","title":{"rendered":"Gonz\u00e1lez, H.L.d.M., et al. Eficacia de la vacuna LaAg asociada a saponina contra la infecci\u00f3n por Leishmania amazonensis."},"content":{"rendered":"<p><strong>Vacunas (Basilea) 2025 Ene 27, 13(2):129. PMID: 40006676 <\/strong><\/p>\n<p>El estudio evalu\u00f3 diferentes formulaciones de vacunas que incorporaban Leishmania amazonensis (LaAg) combinadas con varios adyuvantes, incluidos el adyuvante completo de Freund (CFA), la saponina (SAP) y AddaVax\u2122, para mejorar la inmunogenicidad y la eficacia protectora en ratones BALB\/c.<\/p>\n<p>Entre las formulaciones probadas, la combinaci\u00f3n de LaAg con SAP fue la m\u00e1s eficaz. Indujo significativamente una respuesta de hipersensibilidad retardada (DTH), aument\u00f3 las c\u00e9lulas T CD4+ y CD8+ productoras de IFN-\u03b3 en los ganglios linf\u00e1ticos de drenaje, y dio lugar a una reducci\u00f3n del tama\u00f1o de la lesi\u00f3n y de la carga parasitaria en comparaci\u00f3n con otras formulaciones.<\/p>\n<p>El estudio concluy\u00f3 que los adyuvantes a base de saponina mejoran significativamente la inmunogenicidad y la eficacia de LaAg, convirti\u00e9ndola de una vacuna no protectora a una parcialmente protectora contra L. amazonensis amazonensis. La formulaci\u00f3n LaAg + SAP podr\u00eda ser una candidata potencial para un mayor desarrollo en la investigaci\u00f3n de vacunas contra la leishmaniasis.<\/p>\n<p>Haz clic en <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40006676\/\" target=\"_blank\" rel=\"noopener nofollow\"><strong>aqu\u00ed<\/strong><\/a> para acceder al art\u00edculo cient\u00edfico completo.<\/p>\n<div><\/div>\n<div>\t\t\t<style>\r\n\t\t\t\t#sfba_subscribe_form_531 .subscribeform1 {\r\n\t\t\t\t\twidth: 514px;\r\n\t\t\t\t\tborder: 0px groove rgba(159,51,221,0);\r\n\t\t\t\t\tfont-family: 'Verdana';\r\n\t\t\t\t\tbackground-color: #759e2c;\r\n\t\t\t\t\tbackground-image: url('');\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_531 #sfba-main-form-container.subscribeform1 .sfba-form-sub-heading {\r\n\t\t\t\t\tcolor: #000000;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_531 #sfba-main-form-container.subscribeform1 .sfba-form-privacy-heading {\r\n\t\t\t\t\tcolor: ;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_531 #sfba-main-form-container.subscribeform1 .sfba-form-heading {\r\n\t\t\t\t\tcolor: #ffffff;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_531 .subscribeform1 .sfba_subscribe_form__fields .sfba-form-fields {\r\n\t\t\t\t\tborder-color: rgba(0,0,0,0);\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_531 .subscribeform1 .sfba-form-consent-fields-main label,\r\n\t\t\t\t#sfba_subscribe_form_531 .subscribeform1 .sfba-form-consent-fields-main {\r\n\t\t\t\t\tcolor: #ffffff;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_531 .subscribeform1 #sfba-form-button {\r\n\t\t\t\t\tbackground-color: #4c6938;\r\n\t\t\t\t\tcolor: #ffffff;\r\n\t\t\t\t\tfont-size: 14px;\r\n\t\t\t\t}\r\n\t\t\t\t.subscribeform6 #sfba-form-button {\r\n\t\t\t\t\tbackground-image: url(https:\/\/desertking.com\/wp-content\/plugins\/wp-subscribe-forms-pro\/includes\/..\/images\/sent.png);\r\n\t\t\t\t}\r\n\t\t\t\tinput.sfba-form-fields::placeholder { \/ Chrome, Firefox, Opera, Safari 10.1+ \/\r\n\t\t\t\t  color: #7E7E7E;\r\n\t\t\t\t  opacity: 1; 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