{"id":3428,"date":"2025-04-15T11:07:40","date_gmt":"2025-04-15T14:07:40","guid":{"rendered":"https:\/\/desertkingdev.wpenginepowered.com\/hickey-j-et-al-two-recombinant-cytomegalovirus-antigens-formulated-with-the-spa14-adjuvant-system-impact-of-temperature-ph-and-excipients-on-the-stability-of-each-antigen-and-adjuvant-component\/"},"modified":"2025-04-15T12:32:56","modified_gmt":"2025-04-15T15:32:56","slug":"hickey-j-et-al-two-recombinant-cytomegalovirus-antigens-formulated-with-the-spa14-adjuvant-system-impact-of-temperature-ph-and-excipients-on-the-stability-of-each-antigen-and-adjuvant-component","status":"publish","type":"post","link":"https:\/\/desertking.com\/es\/hickey-j-et-al-two-recombinant-cytomegalovirus-antigens-formulated-with-the-spa14-adjuvant-system-impact-of-temperature-ph-and-excipients-on-the-stability-of-each-antigen-and-adjuvant-component\/","title":{"rendered":"Hickey, J., et al. Dos ant\u00edgenos recombinantes del citomegalovirus formulados con el sistema adyuvante SPA14: Impacto de la temperatura, el pH y los excipientes en la estabilidad de cada ant\u00edgeno y componente adyuvante."},"content":{"rendered":"<p style=\"text-align: justify;\"><strong>J Pharm Sci, 2025 Feb, 114(2):1224-1236. PMID: 39864550 <\/strong><\/p>\n<p style=\"text-align: justify;\">El estudio evalu\u00f3 la estabilidad de dos ant\u00edgenos recombinantes de Citomegalovirus (gB y Pent\u00e1mero) formulados con el sistema adyuvante SPA14, una formulaci\u00f3n liposomal que contiene QS-21 y el agonista sint\u00e9tico de TLR4 E6020. Se realizaron estudios de caracterizaci\u00f3n anal\u00edtica y estabilidad acelerada en diversas condiciones (temperatura, pH y excipientes) para identificar los par\u00e1metros de formulaci\u00f3n que mejoran la estabilidad.<\/p>\n<p style=\"text-align: justify;\">El sistema adyuvante SPA14 indujo una respuesta inmunitaria Th1\/Th2 equilibrada cuando se coformul\u00f3 con ant\u00edgenos del CMV. La presencia de ant\u00edgenos no alter\u00f3 significativamente el tama\u00f1o de part\u00edcula de los liposomas. Sin embargo, peque\u00f1os cambios de pH durante el almacenamiento afectaron negativamente a la integridad de los liposomas y a la estabilidad del QS-21, pero tuvieron un impacto m\u00ednimo sobre el E6020. Adem\u00e1s, las trazas de iones met\u00e1licos contribuyeron a la inestabilidad del QS-21 y el E6020; por ello, la adici\u00f3n de quelantes met\u00e1licos y eliminadores de radicales libres mejor\u00f3 su estabilidad.<\/p>\n<p style=\"text-align: justify;\">Este trabajo subraya la necesidad de una optimizaci\u00f3n espec\u00edfica de la formulaci\u00f3n para mitigar las v\u00edas de degradaci\u00f3n y mejorar la estabilidad general de las vacunas candidatas.<\/p>\n<p>&nbsp;<\/p>\n<p>Haz clic <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39864550\/\" target=\"_blank\" rel=\"noopener nofollow\">aqu\u00ed<\/a> para acceder al art\u00edculo cient\u00edfico completo.<\/p>\n<p>&nbsp;<\/p>\n\t\t\t<style>\r\n\t\t\t\t#sfba_subscribe_form_170 .subscribeform1 {\r\n\t\t\t\t\twidth: 514px;\r\n\t\t\t\t\tborder: 0px groove rgba(159,51,221,0);\r\n\t\t\t\t\tfont-family: 'Verdana';\r\n\t\t\t\t\tbackground-color: #759e2c;\r\n\t\t\t\t\tbackground-image: url('');\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_170 #sfba-main-form-container.subscribeform1 .sfba-form-sub-heading {\r\n\t\t\t\t\tcolor: #000000;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_170 #sfba-main-form-container.subscribeform1 .sfba-form-privacy-heading {\r\n\t\t\t\t\tcolor: ;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_170 #sfba-main-form-container.subscribeform1 .sfba-form-heading {\r\n\t\t\t\t\tcolor: #ffffff;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_170 .subscribeform1 .sfba_subscribe_form__fields .sfba-form-fields {\r\n\t\t\t\t\tborder-color: rgba(0,0,0,0);\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_170 .subscribeform1 .sfba-form-consent-fields-main label,\r\n\t\t\t\t#sfba_subscribe_form_170 .subscribeform1 .sfba-form-consent-fields-main {\r\n\t\t\t\t\tcolor: #ffffff;\r\n\t\t\t\t}\r\n\t\t\t\t#sfba_subscribe_form_170 .subscribeform1 #sfba-form-button {\r\n\t\t\t\t\tbackground-color: #4c6938;\r\n\t\t\t\t\tcolor: #ffffff;\r\n\t\t\t\t\tfont-size: 14px;\r\n\t\t\t\t}\r\n\t\t\t\t.subscribeform6 #sfba-form-button {\r\n\t\t\t\t\tbackground-image: url(https:\/\/desertking.com\/wp-content\/plugins\/wp-subscribe-forms-pro\/includes\/..\/images\/sent.png);\r\n\t\t\t\t}\r\n\t\t\t\tinput.sfba-form-fields::placeholder { \/ Chrome, Firefox, Opera, Safari 10.1+ \/\r\n\t\t\t\t  color: #7E7E7E;\r\n\t\t\t\t  opacity: 1; 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