{"id":3292,"date":"2025-03-18T12:24:03","date_gmt":"2025-03-18T15:24:03","guid":{"rendered":"https:\/\/desertkingdev.wpenginepowered.com\/huis-in-t-veld-l-g-et-al-captacion-de-adyuvantes-a-base-de-saponina-e-induccion-de-la-presentacion-cruzada-de-antigenos-por-celulas-dendriticas-cd11b-y-macrofagos\/"},"modified":"2025-03-26T15:51:26","modified_gmt":"2025-03-26T18:51:26","slug":"saponin-based-adjuvant-uptake-and-induction-of-antigen-cross-presentation-by-cd11b-dendritic-cells-and-macrophages","status":"publish","type":"post","link":"https:\/\/desertking.com\/es\/saponin-based-adjuvant-uptake-and-induction-of-antigen-cross-presentation-by-cd11b-dendritic-cells-and-macrophages\/","title":{"rendered":"Huis In \u2019t Veld, L. G., et al. Saponin-based adjuvant uptake and induction of antigen cross-presentation by CD11b+ dendritic cells and macrophages."},"content":{"rendered":"<p><strong>NPJ Vaccines, 2025 Jan 22, 10(1):15. PMID: 39843492.<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: justify;\">The paper presents several key findings regarding saponin-based adjuvants (SBAs), particularly focusing on their mechanism of action and efficacy in enhancing immune responses. It promotes QS-21, a natural saponin derived from <em>Quillaja Saponaria<\/em> and emphasizes its unique adjuvant properties. The study advocates for further exploration and utilization of QS-21 in vaccine development, particularly for its ability to improve the efficacy of non-live attenuated virus vaccines and cancer immunotherapies.<\/p>\n<p style=\"text-align: justify;\">SBAs are specifically taken up by MHCII low CD11b high bone marrow-derived dendritic cells (BMDCs) and macrophages. This uptake occurs primarily through clathrin-mediated endocytosis, leading to the formation of lipid bodies and translocation of antigens to the cytosol. The study demonstrates that SBAs induce cross-presentation in dendritic cells and bone marrow-derived macrophages, which is crucial for activating CD8+ T cells. This cross-presentation is essential for generating strong cellular immune responses.<\/p>\n<p style=\"text-align: justify;\">SBAs outperform traditional adjuvants, such as aluminum-based adjuvants, in inducing CD8+ T cell-mediated immunity. Initial clinical trials using SBAs have shown an acceptable safety profile and clinical benefits, with enhanced responses observed for both CD4+ and CD8+ T cell epitopes in patients. This paper supports the potential of SBAs in immunotherapy and vaccine strategies.<\/p>\n<p>&nbsp;<\/p>\n<p>Click <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39843492\/\" target=\"_blank\" rel=\"noopener nofollow\">here<\/a> to access the full scientific paper.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The paper presents several key findings regarding saponin-based adjuvants (SBAs), particularly focusing on their mechanism of action and efficacy in enhancing immune responses.<\/p>\n","protected":false},"author":16,"featured_media":3290,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"rs_blank_template":"","rs_page_bg_color":"","slide_template_v7":"","footnotes":""},"categories":[],"tags":[],"class_list":["post-3292","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts\/3292","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/comments?post=3292"}],"version-history":[{"count":0,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts\/3292\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/media\/3290"}],"wp:attachment":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/media?parent=3292"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/categories?post=3292"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/tags?post=3292"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}