{"id":3284,"date":"2025-03-18T12:45:11","date_gmt":"2025-03-18T15:45:11","guid":{"rendered":"https:\/\/desertkingdev.wpenginepowered.com\/ye-l-et-al-effects-of-immune-response-on-different-nano-adjuvants-combined-with-h11-antigen-of-haemonchus-contortus\/"},"modified":"2025-03-25T15:00:43","modified_gmt":"2025-03-25T18:00:43","slug":"ye-l-et-al-effects-of-immune-response-on-different-nano-adjuvants-combined-with-h11-antigen-of-haemonchus-contortus","status":"publish","type":"post","link":"https:\/\/desertking.com\/es\/ye-l-et-al-effects-of-immune-response-on-different-nano-adjuvants-combined-with-h11-antigen-of-haemonchus-contortus\/","title":{"rendered":"Ye, L., et al. Effects of immune response on different nano-adjuvants combined with H11 antigen of Haemonchus contortus."},"content":{"rendered":"<p><strong>Int Immunopharmacol, 2024 Dec 25, 143(Pt 3):113602. PMID: 39536488.<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: justify;\">The study indicates that nano-adjuvants offer a promising alternative to traditional adjuvants for inducing robust and lasting immune responses, particularly in the context of developing vaccines against parasitic infections like Haemonchus contortus.<\/p>\n<p style=\"text-align: justify;\">The effects of nano-adjuvants such as immunostimulating complex matrix (IMX), lipid nanoparticles (LNP), and AddaS03\u2122 differed from traditional adjuvants like QuilA (unformulated). Unlike traditional adjuvants, nano-adjuvants can slow the release of antigens, prolonging the time immune cells have to recognize these antigens, thereby improving the overall immune response. This is particularly important for sustaining long-term immunity. Nano-adjuvants tend to facilitate more complex immune mechanisms, including both cell-mediated (Th1 and Th17 responses) and humoral immune responses, whereas traditional adjuvants like QuilA are more focused on stimulating humoral immunity.<\/p>\n<p style=\"text-align: justify;\"><strong>Comments from Desert King<\/strong>: This paper emphasizes the importance of formulations and particulate adjuvants to improve immunogenicity, which we fully agree with. However, the authors did not select a proper \u201ctraditional\u201d adjuvant or use an appropriate QS-21 formulation for the study. QuilA, although not suitable for human vaccines, is a potent adjuvant. This paper demonstrates that the QuilA-adjuvanted vaccine induced the highest IgM and IgG responses, the highest IFN-\u03b3 cytokine levels, and strong lymphocyte proliferation similar to the nano-adjuvants. QS-21 is one of the most effective adjuvants when properly formulated. QS-21-based nanoparticle adjuvants (e.g., AS01b, Matrix-M, ALFQ, etc.) are proven to be extremely potent formulations and are being tested in multiple clinical trials and approved human vaccine.<\/p>\n<p>&nbsp;<\/p>\n<p>Click <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39536488\/\" target=\"_blank\" rel=\"noopener nofollow\">here<\/a> to access the full scientific paper.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The study indicates that nano-adjuvants offer a promising alternative to traditional adjuvants for inducing robust and lasting immune responses<\/p>\n","protected":false},"author":16,"featured_media":3260,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"rs_blank_template":"","rs_page_bg_color":"","slide_template_v7":"","footnotes":""},"categories":[8],"tags":[],"class_list":["post-3284","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar"],"_links":{"self":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts\/3284","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/comments?post=3284"}],"version-history":[{"count":0,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts\/3284\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/media\/3260"}],"wp:attachment":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/media?parent=3284"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/categories?post=3284"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/tags?post=3284"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}