{"id":1319,"date":"2016-09-06T21:04:23","date_gmt":"2016-09-06T21:04:23","guid":{"rendered":"http:\/\/desertkingdev.wpenginepowered.com\/2016\/09\/06\/qs21-nano-patch-queensland-u-2016\/"},"modified":"2025-03-13T21:41:48","modified_gmt":"2025-03-14T00:41:48","slug":"qs21-nano-patch-queensland-u-2016","status":"publish","type":"post","link":"https:\/\/desertking.com\/es\/qs21-nano-patch-queensland-u-2016\/","title":{"rendered":"QS21 Nano Patch Queensland U 2016"},"content":{"rendered":"<div class=\"page\" title=\"Page 1\">\n<div class=\"section\">\n<div class=\"layoutArea\">\n<div class=\"column\">\n<h3><strong>Potent response of QS-21 as a\u00a0vaccine adjuvant in the skin when\u00a0delivered with the Nanopatch,\u00a0resulted in adjuvant dose sparing.<\/strong><\/h3>\n<p><strong>Hwee-Ing Ng, Germain J. P. Fernando, Alexandra C. I. Depelsenaire &amp;\u00a0Mark A. F. Kendall<\/strong><\/p>\n<div class=\"page\" title=\"Page 1\">\n<div class=\"section\">\n<div class=\"layoutArea\">\n<div class=\"column\">\n<p>Adjuvants play a key role in boosting immunogenicity of vaccines, particularly for subunit protein vaccines. In this study we investigated the induction of antibody response against trivalent in uenza subunit protein antigen and a saponin adjuvant, QS-21. Clinical trials of QS-21 have demonstrated<br \/>\nthe safety but, also a need of high dose for optimal immunity, which could possibly reduce patient acceptability. Here, we proposed the use of a skin delivery technology \u2013 the Nanopatch \u2013 to reduce both adjuvant and antigen dose but also retain its immune stimulating e ects when compared to the conventional needle and syringe intramuscular (IM) delivery. We have demonstrated that Nanopatch delivery to skin requires only 1\/100th of the IM antigen dose to induce equivalent humoral response. QS-21 enhanced humoral response in both skin and muscle route. Additionally, Nanopatch has demonstrated 30-fold adjuvant QS-21 dose sparing while retaining immune stimulating e ects compared to IM. QS-21 induced localised, controlled cell death in the skin, suggesting that the danger signals released from dead cells contributed to the enhanced immunogenicity. Taken together, these ndings demonstrated the suitability of reduced dose of QS-21 and the antigen using the Nanopatch to enhance humoral responses, and the potential to increase patient acceptability of QS-21 adjuvant.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"wp-block-pdfemb-pdf-embedder-viewer\"><a href=\"https:\/\/desertking.com\/wp-content\/uploads\/2016\/09\/QS21-Nano-Patch-Queensland-U-2016.pdf\" class=\"pdfemb-viewer\" style=\"\" data-width=\"max\" data-height=\"max\" data-toolbar=\"bottom\" data-toolbar-fixed=\"off\">QS21 Nano Patch Queensland U 2016<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Potent response of QS-21 as a\u00a0vaccine adjuvant in the skin when\u00a0delivered with the Nanopatch,\u00a0resulted in adjuvant dose sparing. Hwee-Ing Ng, Germain J. P. Fernando, Alexandra C. I. Depelsenaire &amp;\u00a0Mark A. F. Kendall Adjuvants play a key role in boosting immunogenicity of vaccines, particularly for subunit protein vaccines. In this study we investigated the induction of [&hellip;]<\/p>\n","protected":false},"author":16,"featured_media":2219,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rs_blank_template":"","rs_page_bg_color":"","slide_template_v7":"","footnotes":""},"categories":[9],"tags":[],"class_list":["post-1319","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts\/1319","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/comments?post=1319"}],"version-history":[{"count":0,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/posts\/1319\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/media\/2219"}],"wp:attachment":[{"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/media?parent=1319"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/categories?post=1319"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/desertking.com\/es\/wp-json\/wp\/v2\/tags?post=1319"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}